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AB163728

Recombinant Human ELAC2 protein (GST tag N-Terminus)

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Recombinant Human ELAC2 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 826 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

HPC2, ELAC2, Zinc phosphodiesterase ELAC protein 2, ElaC homolog protein 2, Heredity prostate cancer protein 2, Ribonuclease Z 2, tRNA 3 endonuclease 2, tRNase Z 2, RNase Z 2

1 Images
SDS-PAGE - Recombinant Human ELAC2 protein (GST tag N-Terminus) (AB163728)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human ELAC2 protein (GST tag N-Terminus) (AB163728)

ab163728 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q9BQ52

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Recombinant Human ZAN protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human ZAN protein (GST tag N-Terminus) (AB159808)

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Proteins & Peptides

AB159886

Recombinant Human ZP2 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human ZP2 protein (GST tag N-Terminus) (AB159886)

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AB161165

Recombinant Human WASF3 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human WASF3 protein (GST tag N-Terminus) (AB161165)

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Primary Antibodies

AB205948

Anti-ELAC2 antibody

Immunoprecipitation - Anti-ELAC2 antibody (AB205948)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MWALCSLLRSAAGRTMSQGRTISQAPARRERPRKDPLRHLRTREKRGPSGCSGGPNTVYLQVVAAGSRDSGAALYVFSEFNRYLFNCGEGVQRLMQEHKLKVARLDNIFLTRMHWSNVGGLSGMILTLKETGLPKCVLSGPPQLEKYLEAIKIFSGPLKGIELAVRPHSAPEYEDETMTVYQIPIHSEQRRGKHQPWQSPERPLSRLSPERSSDSELNENEPHLPHGVSQRRGVRDSSLVVAFICKLHLKRGNFLVLKAKEMGLPVGTAAIAPIIAAVKDGKSITHEGREILAEELCTPPDPGAAFVVVECPDESFIQPICENATFQRYQGKADAPVALVVHMAPASVLVDSRYQQWMERFGPDTQHLVLNENCASVHNLRSHKIQTQLNLIHPDIFPLLTSFRCKKEGPTLSVPMVQGECLLKYQLRPRREWQRDAIITCNPEEFIVEALQLPNFQQSVQEYRRSAQDGPAPAEKRSQYPEIIFLGTGSAIPMKIRNVSATLVNISPDTSLLLDCGEGTFGQLCRHYGDQVDRVLGTLAAVFVSHLHADHHTGLPSILLQRERALASLGKPLHPLLVVAPNQLKAWLQQYHNQCQEVLHHISMIPAKCLQEGAEISSPAVERLISSLLRTCDLEEFQTCLVRHCKHAFGCALVHTSGWKVVYSGDTMPCEALVRMGKDATLLIHEATLEDGLEEEAVEKTHSTTSQAISVGMRMNAEFIMLNHFSQRYAKVPLFSPNFSEKVGVAFDHMKVCFGDFPTMPKLIPPLKALFAGDIEEMEERREKRELRQVRAALLSRELAGGLEDGEPQQKRAHTEEPQAKKVRAQ","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":826,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9BQ52","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ELAC2 also known as ElaC ribonuclease Z 2 functions as an RNase Z-like enzyme with primary responsibility for processing tRNA molecules by cutting the 3' ends. With a mass of approximately 93 kDa ELAC2 localizes mainly in the nucleus and mitochondria expressing in various human tissues. As an essential component of RNA maturation mechanisms it ensures appropriate RNA synthesis and function within cellular contexts.
Biological function summary

The ELAC2 protein contributes significantly to the maturation and stability of transfer RNAs. It forms a part of the ribonuclease Z (RNase Z) family. ELAC2 activity facilitates the specific removal of 3′ trailer sequences from precursor tRNAs which is important for tRNA functionality and stability. It partners with other proteins to maintain cellular homeostasis and ensure accurate protein translation by processing tRNA precursors effectively.

Pathways

ELAC2 integrates into the broader RNA processing and stability pathways highlighting its significant role in tRNA maturation. Within these pathways ELAC2 interacts with proteins like ELAC1 which share similar catalytic activities albeit with different specificity or localization. These interactions and active participation in RNA processing pathways demonstrate ELAC2’s importance toward maintaining proper cellular function and gene expression regulation.

ELAC2 has associations with prostate cancer and cardiac hypertrophy. In prostate cancer ELAC2 mutations or dysregulation may result in altered RNA processing affecting cellular growth and differentiation. Moreover in cardiac hypertrophy ELAC2 potentially influences myocardial growth by impacting mitochondrial RNA processing. ELAC2-related dysfunctions could therefore offer insight into disease mechanisms alongside proteins like RNASEL which also contribute to these conditions.
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Specifications

Form

Liquid

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General info

Function

Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (PubMed : 21593607). Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly (PubMed : 24703694).

Sequence similarities

Belongs to the RNase Z family.

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Product protocols

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Target data

Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (PubMed : 21593607). Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly (PubMed : 24703694).
See full target information ELAC2
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