Recombinant Human Elafin/ESI protein is a Human Full Length protein, in the 23 to 117 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
>95% SDS-PAGE
< 1 EU/µg
HEK 293 cells
His tag C-Terminus
SDS-PAGE
No
A V T G V P V K G Q D T V K G R V P F N G Q D P V K G Q V S V K G Q D K V K A Q E P V K G P V S T K P G S C P I I L I R C A M L N P P N R C L K D T D C P G I K K C C E G S C G M A C F V P Q
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1) (PubMed:29483648).
WAP3, WFDC14, PI3, WAP3, WFDC14, Elafin, Elastase-specific inhibitor, Peptidase inhibitor 3, Protease inhibitor WAP3, Skin-derived antileukoproteinase, WAP four-disulfide core domain protein 14, ESI, PI-3, SKALP
Recombinant Human Elafin/ESI protein is a Human Full Length protein, in the 23 to 117 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
>95% SDS-PAGE
< 1 EU/µg
HEK 293 cells
His tag C-Terminus
SDS-PAGE
No
No
Human
pH: 7.5
Constituents: 0.88% Sodium chloride, 0.32% Tris HCl
A V T G V P V K G Q D T V K G R V P F N G Q D P V K G Q V S V K G Q D K V K A Q E P V K G P V S T K P G S C P I I L I R C A M L N P P N R C L K D T D C P G I K K C C E G S C G M A C F V P Q
Full Length
9.9 kDa
23 to 117
Recombinant
His tag C-Terminus
Liquid
Purity is greater than 95% as determined by reducing SDS-PAGE. ab153768 is supplied as a 0.2 µm filtered solution.
Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1) (PubMed:29483648).
Dry Ice
-80°C
-80°C
Upon delivery aliquot
Avoid freeze / thaw cycle
Previously labelled as Elafin/Skalp.
This supplementary information is collated from multiple sources and compiled automatically.
Elafin also known as ESI or ESI protein is a small serine protease inhibitor with a molecular mass of around 6 kDa. This protein produced by epithelial cells resides predominantly in the skin lungs and other mucosal surfaces. The Elafin protein plays an important mechanical role in inhibiting neutrophil elastase and proteinase 3. It contributes to the regulation of protease activity within tissues controlling inflammation and repair processes.
Elafin interacts intimately with protease inhibitors to guard tissues against excessive proteolytic damage. It does not typically form large complexes but functions as part of the innate immune defense. This protein helps to neutralize the action of neutrophil elastase which can help maintain the integrity of connective tissue extracellular matrix. Despite its standalone function Elafin's activity serves in tandem with other inhibitors in the protease-antiprotease balance.
Elafin integrates prominently into the proteolytic and inflammatory pathways. It functions particularly in the inflammation and immune response pathways coordinating with proteins like secretory leukocyte protease inhibitor (SLPI) and alpha-1 antitrypsin. Elafin inhibits enzymes that degrade connective tissue components. Therefore it plays an important role in modulating inflammatory responses and tissue remodeling post-injury.
Connections between Elafin and conditions such as chronic obstructive pulmonary disease (COPD) and psoriasis appear significant. These diseases relate to abnormal protease activity and chronic inflammation where Elafin's inhibitory function can be affected or diminished. Studies have shown that altered Elafin levels link with these diseases alongside proteins like neutrophil elastase and matrix metalloproteinases which contribute to tissue damage. Researchers continue to explore Elafin's therapeutic potential in managing such inflammatory conditions.
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