JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB183175

Recombinant Human Elongation factor 1-gamma protein

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human Elongation factor 1-gamma protein is a Human Full Length protein, in the 1 to 437 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE.

View Alternative Names

EF1G, PRO1608, EEF1G, Elongation factor 1-gamma, EF-1-gamma, eEF-1B gamma

1 Images
SDS-PAGE - Recombinant Human Elongation factor 1-gamma protein (AB183175)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Elongation factor 1-gamma protein (AB183175)

15% SDS-PAGE analysis of ab183175 (3μg).

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P26641

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

Product details

Previously labelled as EEF1G.

Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMAAGTLYTYPENWRAFKALIAAQYSGAQVRVLSAPPHFHFGQTNRTPEFLRKFPAGKVPAFEGDDGFCVFESNAIAYYVSNEELRGSTPEAAAQVVQWVSFADSDIVPPASTWVFPTLGIMHHNKQATENAKEEVRRILGLLDAYLKTRTFLVGERVTLADITVVCTLLWLYKQVLEPSFRQAFPNTNRWFLTCINQPQFRAVLGEVKLCEKMAQFDAKKFAETQPKKDTPRKEKGSREEKQKPQAERKEEKKAAAPAPEEEMDECEQALAAEPKAKDPFAHLPKSTFVLDEFKRKYSNEDTLSVALPYFWEHFDKDGWSLWYSEYRFPEELTQTFMSCNLITGMFQRLDKLRKNAFASVILFGTNNSSSISGVWVFRGQELAFPLSPDWQVDYESYTWRKLDPGSEETQTLVREYFSWEGAFQHVGKAFNQGKIFK","proteinLength":"Full Length","predictedMolecularWeight":"52.57 kDa","actualMolecularWeight":null,"aminoAcidEnd":437,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P26641","tags":[{"tag":"His","terminus":"N-Terminus"}]}]

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Elongation factor 1-gamma sometimes called EF-1γ is a protein that plays an important role in the process of protein biosynthesis. It is part of the elongation factor complex essential for the elongation phase of translation. This protein has a molecular weight of about 50 kDa. EF-1γ is expressed ubiquitously meaning it is found in many different types of tissues throughout the body indicating its broad necessity for cellular function.
Biological function summary

Elongation factor 1-gamma supports the stability and functionality of the larger elongation factor 1 complex which also includes EF-1 alpha EF-1 beta and EF-1 delta. This complex facilitates the economic and rapid engagement of aminoacyl-tRNA to the ribosome's A-site which is important in the synthesis of proteins ensuring that proteins are accurately and efficiently elongated during translation.

Pathways

Elongation factor 1-gamma has significance in the translation pathway and is also linked to the mTOR signaling pathway. The translation pathway is fundamental for general protein synthesis while the mTOR pathway is pivotal in regulating cell growth and proliferation. In these contexts elongation factor 1-gamma associates with other proteins such as elongation factor 1 alpha to optimize the elongation step of protein synthesis impacting cell growth and survival.

Elongation factor 1-gamma shows connections to certain cancer types and neurodegenerative diseases. In cancer alterations or dysregulations of EF-1γ expression can influence tumor growth and development. Meanwhile relation to neurodegenerative disorders is under study as EF-1γ participates in protein synthesis with possible impacts on neuronal survival. Elongation factor 1-gamma’s interactions with proteins like EF-1 alpha in these conditions spotlight its importance to cellular homeostasis and pathology.

Specifications

Form

Liquid

Additional notes

ab183175 is purified using anion-exchange chromatography (DEAE sepharose resin) and gel-filtration chromatography (Sephacryl S-200) with 20 mM Tris pH 7.5, 2 mM EDTA.

General info

Function

Probably plays a role in anchoring the complex to other cellular components.

Product protocols

Target data

Probably plays a role in anchoring the complex to other cellular components.
See full target information EEF1G

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com