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AB162883

Recombinant Human ELOVL2 protein (GST tag N-Terminus)

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Recombinant Human ELOVL2 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 296 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

ELG3, SSC2, ELOVL2, Very long chain fatty acid elongase 2, 3-keto acyl-CoA synthase ELOVL2, ELOVL fatty acid elongase 2, Elongation of very long chain fatty acids protein 2, Very long chain 3-ketoacyl-CoA synthase 2, Very long chain 3-oxoacyl-CoA synthase 2, ELOVL FA elongase 2

1 Images
SDS-PAGE - Recombinant Human ELOVL2 protein (GST tag N-Terminus) (AB162883)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human ELOVL2 protein (GST tag N-Terminus) (AB162883)

ab162883 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q9NXB9

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MEHLKAFDDEINAFLDNMFGPRDSRVRGWFMLDSYLPTFFLTVMYLLSIWLGNKYMKNRPALSLRGILTLYNLGITLLSAYMLAELILSTWEGGYNLQCQDLTSAGEADIRVAKVLWWYYFSKSVEFLDTIFFVLRKKTSQITFLHVYHHASMFNIWWCVLNWIPCGQSFFGPTLNSFIHILMYSYYGLSVFPSMHKYLWWKKYLTQAQLVQFVLAITHTMSAVVKPCGFPFGCLIFQSSYMLTLVILFLNFYVQTYRKKPMKKDMQEPPAGKEVKNGFSKAYFTAANGVMNKKAQ","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":296,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9NXB9","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein ELOVL2 also known as Elongation of very long chain fatty acids protein 2 plays an important role in the elongation of long-chain polyunsaturated fatty acids. Its molecular mass is approximately 33 kDa. ELOVL2 is expressed highly in the liver retina and testes indicating its importance in these tissues where long-chain fatty acids are critical.
Biological function summary

ELOVL2 functions in the biosynthesis of polyunsaturated fatty acids which are essential components of phospholipids and are involved in various cellular processes. Although ELOVL2 does not form part of a larger protein complex its enzymatic activity significantly impacts membrane fluidity and function. This fatty acid elongation process supports cellular homeostasis and influences signaling pathways.

Pathways

ELOVL2 serves a critical role in the fatty acid elongation pathway. Its activity is closely linked with enzymes like fatty acid desaturases which together maintain lipid composition within membranes. The function of ELOVL2 contributes importantly to the metabolism of fatty acids enabling the synthesis of eicosanoids and docosanoids which are vital signaling molecules.

ELOVL2 has been associated with age-related decline in physiological functions such as vision and metabolic syndromes like diabetes. Research suggests a connection between alterations in its activity with proteins such as FADS2 which participate in fatty acid metabolism can influence these conditions. Understanding the role of ELOVL2 in these diseases may offer potential therapeutic targets to mitigate their progression.
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Specifications

Form

Liquid

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General info

Function

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA), acting specifically toward polyunsaturated acyl-CoA with the higher activity toward C20 : 4(n-6) acyl-CoA. May participate in the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

Sequence similarities

Belongs to the ELO family. ELOVL2 subfamily.

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Product protocols

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Target data

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA), acting specifically toward polyunsaturated acyl-CoA with the higher activity toward C20 : 4(n-6) acyl-CoA. May participate in the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
See full target information ELOVL2
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