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AB187472

Recombinant Human Elp4 protein (denatured)

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Recombinant Human Elp4 protein (denatured) is a Human Full Length protein, in the 1 to 424 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE.

View Alternative Names

C11orf19, PAXNEB, ELP4, Elongator complex protein 4, hELP4, PAX6 neighbor gene protein

1 Images
SDS-PAGE - Recombinant Human Elp4 protein (denatured) (AB187472)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Elp4 protein (denatured) (AB187472)

15% SDS-PAGE analysis of ab187472 (3μg).

Key facts

Purity

>80% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q96EB1

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMAAVATCGSVAASTGSAVATASKSNVTSFQRRGPRASVTNDSGPRLVSIAGTRPSVRNGQLLVSTGLPALDQLLGGGLAVGTVLLIEEDKYNIYSPLLFKYFLAEGIVNGHTLLVASAKEDPANILQELPAPLLDDKCKKEFDEDVYNHKTPESNIKMKIAWRYQLLPKMEIGPVSSSRFGHYYDASKRMPQELIEASNWHGFFLPEKISSTLKVEPCSLTPGYTKLLQFIQNIIYEEGFDGSNPQKKQRNILRIGIQNLGSPLWGDDICCAENGGNSHSLTKFLYVLRGLLRTSLSACIITMPTHLIQNKAIIARVTTLSDVVVGLESFIGSERETNPLYKDYHGLIHIRQIPRLNNLICDESDVKDLAFKLKRKLFTIERLHLPPDLSDTVSRSSKMDLAESAKRLGPGCGMMAGGKKHLDF","proteinLength":"Full Length","predictedMolecularWeight":"49 kDa","actualMolecularWeight":null,"aminoAcidEnd":424,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q96EB1","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Elp4 also known as Elongator complex protein 4 has an important role in the transcription process within cells. Its molecular weight is approximately 46 kDa. Elp4 is expressed in multiple tissues throughout the body with higher presence observed in the brain. It works as a component of the larger Elongator complex collaborating with other proteins such as Elp1 Elp2 Elp3 Elp5 and Elp6.
Biological function summary

Elongator complex proteins contribute to various cellular functions. Elp4 plays an important role in facilitating the modification of tRNA molecules necessary for efficient protein translation. It acts as part of the Elongator complex which participates in transcriptional elongation impacting processes like acetylation of histone 3 lysine 14. Elp4's activity in these processes ensures the proper progression and regulation of gene expression.

Pathways

Elp4 integrates into several significant cellular pathways. Notably it is active in the transcriptional elongation pathway an important process for proper gene expression. It also interacts with the oxidative stress response pathway aiding cells to manage stress. Within these pathways Elp4 collaborates closely with other elements of the Elongator complex ensuring synchronized functioning in transcription and stress response.

Research indicates that mutations or dysfunctions in Elp4 can contribute to several neurological conditions particularly juvenile-onset dystonia. This connection links Elp4 indirectly with other proteins involved in neural function such as dopamine receptor pathways. Additionally Elp4 is implicated in neurodevelopmental disorders like Rolandic epilepsy where its interaction with other components in the neuronal signaling may be disrupted.
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Specifications

Form

Liquid

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General info

Function

Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed : 29332244). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed : 29332244).

Sequence similarities

Belongs to the ELP4 family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed : 29332244). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed : 29332244).
See full target information ELP4
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