Recombinant Human EMILIN2 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

EMILIN2 also known as Elastin Microfibril Interface Located Protein 2 is a protein with a mass of approximately 85 kDa. It is found in extracellular matrix components and is expressed in multiple tissues including blood vessels skin and certain muscular tissues. EMILIN2 interacts with other extracellular proteins and plays an essential role in maintaining structural integrity and elasticity in these tissues.

Biological function summary

EMILIN2 influences cell adhesion and migration by interacting with integrins and other extracellular matrix proteins. It forms part of the large multimolecular complex that resides in the basement membrane zone. EMILIN2 plays an important role in controlling cellular processes essential for tissue homeostasis and repair mechanisms contributing to cell signaling pathways that guide cellular responses to environmental cues.

Pathways

EMILIN2 participates in modulating the Notch signaling pathway and extracellular matrix organization. By influencing these pathways EMILIN2 works with proteins such as fibronectin and laminins which are important for cellular communication and structural support. The interplay between EMILIN2 and these pathways is significant for maintaining cellular function and tissue architecture.

EMILIN2 has links to cardiovascular diseases and certain types of skin diseases. Alterations in the expression or function of EMILIN2 can contribute to the pathophysiology of these conditions. Additionally EMILIN2 is connected to the progression of atherosclerosis through its interaction with proteins like elastin which affects vascular elasticity and integrity. Understanding EMILIN2's role in these diseases aids in developing therapeutic strategies targeting the extracellular matrix components.