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AB130024

Recombinant Human Endomucin protein (His tag N-Terminus)

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Recombinant Human Endomucin protein (His tag N-Terminus) is a Human Fragment protein, in the 19 to 190 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

EMCN2, MUC14, EMCN, Endomucin, Endomucin-2, Gastric cancer antigen Ga34, Mucin-14, MUC-14

1 Images
SDS-PAGE - Recombinant Human Endomucin protein (His tag N-Terminus) (AB130024)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Endomucin protein (His tag N-Terminus) (AB130024)

15% SDS-PAGE analysis of 3 μg ab130024.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q9ULC0

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMNSTGVLEAANNSLVVTTTKPSITTPNTESLQKNVVTPTTGTTPKGTITNELLKMSLMSTATFLTSKDEGLKATTTDVRKNDSIISNVTVTSVTLPNAVSTLQSSKPKTETQSSIKTTEIPGSVLQPDASPSKTGTLTSIPVTIPENTSQSQVIGTEGGKNASTSATSRSYSS","proteinLength":"Fragment","predictedMolecularWeight":"20.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":190,"aminoAcidStart":19,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9ULC0","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Endomucin also known as EMCN is a glycoprotein with a molecular mass of approximately 75 kDa. As part of the endothelial glycocalyx endomucin is expressed predominantly in endothelial cells lining blood vessels. This protein is involved in the prevention of leukocyte-endothelial cell adhesion and regulates cell surface exposure of adhesion molecules. Endomucin’s expression can be detected in tissues with high vascularization such as the heart and lungs.
Biological function summary

Endomucin modulates the vascular permeability and the anti-inflammatory responses of endothelial tissues. It interacts with other proteins within the endothelial cell surface matrix forming a complex with proteoglycans and glycoproteins. Through these interactions endomucin plays an important role in maintaining endothelial barrier integrity and vascular homeostasis contributing to the regulation of angiogenesis and endothelial cell function.

Pathways

Endomucin engages in the regulation of the inflammatory and angiogenic pathways. It modulates the Notch signaling pathway which is key for maintaining vascular development and function. Additionally interactions with components like vascular endothelial growth factor (VEGF) highlight its involvement in angiogenic processes closely linking endomucin to pathways that govern cell proliferation and migration in endothelial tissues.

Endomucin is significantly linked to inflammatory diseases such as atherosclerosis and cardiovascular abnormalities. In these contexts it interacts with adhesion molecules such as E-selectin influencing the progression of inflammation and vascular inflammation. Altered expression or dysfunction of endomucin could potentially contribute to these diseases underlining its relevance in vascular pathophysiology and endothelial health.
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Specifications

Form

Liquid

Additional notes

ab130024 was purified using conventional chromatography techniques.

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General info

Function

Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.

Post-translational modifications

Highly O-glycosylated. Sialic acid-rich glycoprotein.

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Product protocols

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Target data

Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.
See full target information EMCN
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Complementary Products

Primary Antibodies

AB106100

Anti-Endomucin antibody [V.7C7.1]

Immunocytochemistry/ Immunofluorescence - Anti-Endomucin antibody [V.7C7.1] (AB106100)

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Primary Antibodies

AB215912

Alexa Fluor® 647 Anti-CD31 antibody [JC/70A]

Immunocytochemistry - Alexa Fluor® 647 Anti-CD31 antibody [JC/70A] (AB215912)

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Primary Antibodies

AB15580

Anti-Ki67 antibody

BOND RX™ Validated|KO Validated

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Primary Antibodies

AB81289

Anti-CD34 antibody [EP373Y]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Flow Cytometry (Intracellular) - Anti-CD34 antibody [EP373Y] (AB81289)

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