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AB140557

Recombinant Human Endothelin 2/ET-2 protein (denatured)

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Recombinant Human Endothelin 2/ET-2 protein (denatured) is a Human Full Length protein, in the 25 to 178 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

Endothelin-2, ET-2, Preproendothelin-2, PPET2, EDN2

1 Images
SDS-PAGE - Recombinant Human Endothelin 2/ET-2 protein (denatured) (AB140557)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Endothelin 2/ET-2 protein (denatured) (AB140557)

15% SDS-PAGE analysis of ab140557 (3μg)

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P20800

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as Endothelin 2
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSQAAATLEQPASSSHAQGTHLRLRRCSCSSWLDKECVYFCHLDIIWVNTPEQTAPYGLGNPPRRRRRSLPRRCQCSSARDPACATFCLRRPWTEAGAVPSRKSPADVFQTGKTGATTGELLQRLRDISTVKSLFAKRQQEAMREPRSTHSRWRKR","proteinLength":"Full Length","predictedMolecularWeight":"19.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":178,"aminoAcidStart":25,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P20800","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Endothelin 2 (ET-2) also known as EDN2 is a small peptide with a molecular mass of approximately 2.5 kDa. It belongs to the endothelin family of peptides which includes three isopeptides: ET-1 ET-2 and ET-3. ET-2 expresses in various tissues with notable abundance in the kidney intestines and ovary. The peptide functions by binding to endothelin receptors mainly ETA and ETB on the surface of cells facilitating a range of physiological responses.
Biological function summary

Endothelin 2 modulates vasoconstriction and plays a role in blood pressure regulation. ET-2 functions in tandem with endothelin receptors forming part of a complex signaling network. It influences processes like smooth muscle contraction and cellular proliferation. Additionally ET-2 involves itself in reproductive function particularly within female reproductive tissues affecting ovarian physiology.

Pathways

Endothelin 2 integrates into the endothelin signaling pathway which is pivotal for vascular tone regulation. It interacts with other critical components such as ET-1 within this pathway. ET-2 also relates to the MAPK/ERK pathway which governs cell growth and differentiation. Through these pathways ET-2 coordinates tissue responses to various physiological stimuli often in conjunction with proteins like endothelin receptors and MAPKs.

Endothelin 2 shows a link to conditions such as hypertension and polycystic ovary syndrome (PCOS). Aberrant ET-2 expression can contribute to vascular dysfunction in hypertension. In PCOS ET-2 may regulate ovarian stroma and granulosa cell function with potential connections to proteins like follicle-stimulating hormone (FSH) highlighting its importance in reproductive pathophysiology.
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Specifications

Form

Liquid

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General info

Function

Endothelins are endothelium-derived vasoconstrictor peptides.

Sequence similarities

Belongs to the endothelin/sarafotoxin family.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Endothelins are endothelium-derived vasoconstrictor peptides.
See full target information EDN2
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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