Recombinant Human Endothelin B Receptor/ET-B protein (GST tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

Endothelin B receptor is involved in the regulation of vascular tone blood pressure and fluid-electrolyte balance. It does not function in isolation; it often forms a complex with other proteins including G proteins which help transduce signals into cells leading to a variety of physiological responses. ET-B induces vasodilation by releasing nitric oxide and prostacyclin when activated on endothelial cells. It also plays a role in modulating neural crest cell migration during development which affects pigmentation and enteric nervous system formation.

Pathways

Endothelin B receptor is prominently involved in the endothelin signaling pathway and vascular endothelial growth factor (VEGF) pathway. In the endothelin pathway ET-B works alongside its relative endothelin A receptor (ET-A) to finely balance vasodilation and vasoconstriction processes. In the context of VEGF pathway ET-B is involved in angiogenesis aiding in the growth of new blood vessels. Its interactions include signaling molecules like nitric oxide synthase which contributes to its role in endothelial function and blood pressure regulation.