Recombinant Human ENOX2/tNOX protein (Tagged) is a Human Full Length protein, in the 1 to 610 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE.
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Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- Tag free
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M Q R D F R W L W V Y E I G Y A A D N S R T L N V D S T A M T L P M S D P T A W A T A M N N L G M A P L G I A G Q P I L P D F D P A L G M M T G I P P I T P M M P G L G I V P P P I P P D M P V V K E I I H C K S C T L F P P N P N L P P P A T R E R P P G C K T V F V G G L P E N G T E Q I I V E V F E Q C G E I I A I R K S K K N F C H I R F A E E Y M V D K A L Y L S G Y R I R L G S S T D K K D T G R L H V D F A Q A R D D L Y E W E C K Q R M L A R E E R H R R R M E E E R L R P P S P P P V V H Y S D H E C S I V A E K L K D D S K F S E A V Q T L L T W I E R G E V N R R S A N N F Y S M I Q S A N S H V R R L V N E K A A H E K D M E E A K E K F K Q A L S G I L I Q F E Q I V A V Y H S A S K Q K A W D H F T K A Q R K N I S V W C K Q A E E I R N I H N D E L M G I R R E E E M E M S D D E I E E M T E T K E T E E S A L V S Q A E A L K E E N D S L R W Q L D A Y R N E V E L L K Q E Q G K V H R E D D P N K E Q Q L K L L Q Q A L Q G M Q Q H L L K V Q E E Y K K K E A E L E K L K D D K L Q V E K M L E N L K E K E S C A S R L C A S N Q D S E Y P L E K T M N S S P I K S E R E A L L V G I I S T F L H V H P F G A S I E Y I C S Y L H R L D N K I C T S D V E C L M G R L Q H T F K Q E M T G V G A S L E K R W K F C G F E G L K L T
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock.
Alternative names
COVA1, ENOX2, Ecto-NOX disulfide-thiol exchanger 2, APK1 antigen, Cytosolic ovarian carcinoma antigen 1, Tumor-associated hydroquinone oxidase, tNOX
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Recombinant Human ENOX2/tNOX protein (Tagged) is a Human Full Length protein, in the 1 to 610 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- Tag free
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q16206-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.2 - 7.4
Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)
Sequence info
Amino acid sequence
- M Q R D F R W L W V Y E I G Y A A D N S R T L N V D S T A M T L P M S D P T A W A T A M N N L G M A P L G I A G Q P I L P D F D P A L G M M T G I P P I T P M M P G L G I V P P P I P P D M P V V K E I I H C K S C T L F P P N P N L P P P A T R E R P P G C K T V F V G G L P E N G T E Q I I V E V F E Q C G E I I A I R K S K K N F C H I R F A E E Y M V D K A L Y L S G Y R I R L G S S T D K K D T G R L H V D F A Q A R D D L Y E W E C K Q R M L A R E E R H R R R M E E E R L R P P S P P P V V H Y S D H E C S I V A E K L K D D S K F S E A V Q T L L T W I E R G E V N R R S A N N F Y S M I Q S A N S H V R R L V N E K A A H E K D M E E A K E K F K Q A L S G I L I Q F E Q I V A V Y H S A S K Q K A W D H F T K A Q R K N I S V W C K Q A E E I R N I H N D E L M G I R R E E E M E M S D D E I E E M T E T K E T E E S A L V S Q A E A L K E E N D S L R W Q L D A Y R N E V E L L K Q E Q G K V H R E D D P N K E Q Q L K L L Q Q A L Q G M Q Q H L L K V Q E E Y K K K E A E L E K L K D D K L Q V E K M L E N L K E K E S C A S R L C A S N Q D S E Y P L E K T M N S S P I K S E R E A L L V G I I S T F L H V H P F G A S I E Y I C S Y L H R L D N K I C T S D V E C L M G R L Q H T F K Q E M T G V G A S L E K R W K F C G F E G L K L T
- Accession
- Q16206
- Protein length
- Full Length
- Predicted molecular weight
- 77.1 kDa
- Amino acids
- 1 to 610
- Nature
- Recombinant
Specifications
- Form
- Liquid
General info
- Function
May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock.
- Sequence similarities
Belongs to the ENOX family.
- Post-translational modifications
Glycosylated.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Avoid freeze / thaw cycle
Notes
Previously labelled as ENOX2.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
ENOX2 also known as tumor-associated NADH oxidase or tNOX is a protein involved in cellular processes including growth and apoptosis. It has a molecular mass of approximately 46 kDa and exhibits unique activity patterns cycling with a 24-minute period. ENOX2 is expressed mostly in cancer cells but not in normal cells which makes it a potential biomarker for various types of cancer. This expression pattern offers a significant advantage for targeted cancer therapies focusing efforts on treating malignant cells while sparing healthy tissues.
- Biological function summary
This enzyme plays a role in electron transport and cell surface NADH oxidase activity. ENOX2 forms part of a complex involved in the regulation of cellular energy and growth directly impacting cellular proliferation rates. It contributes to the maintenance of extracellular environments that support cancer cell survival and proliferation. Its activity parallels growth rates in cancer cells further implicating its function in tumorigenesis and oncogenic processes.
- Pathways
ENOX2 operates within the NADH/NAD+ redox system and impacts the pathways that govern cellular metabolism and energy flow. It interacts with proteins in the oxidative phosphorylation pathway which is critical for ATP production and cellular energy regulation. ENOX2 links to proteins such as cytochrome c oxidase and its influence extends to pathways associated with glycolytic processes and mitochondrial function illustrating its central part in metabolic reprogramming in cancer cells.
- Associated diseases and disorders
ENOX2 is strongly associated with cancer serving as both a diagnostic marker and a potential therapeutic target. Its cancer-specific expression pattern exposes its linkage to oncogenic pathways. ENOX2 is connected to other proteins implicated in cancer such as HER2/neu playing a role in breast cancer. Additionally it relates to neurodegenerative disorders where alterations in cellular metabolism contribute to disease progression although the precise mechanisms remain under investigation.
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1 product image
SDS-PAGE - Recombinant Human ENOX2/tNOX protein (Tagged) (ab235678)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel of ab235678.
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