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AB235678

Recombinant Human ENOX2/tNOX protein (Tagged)

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Recombinant Human ENOX2/tNOX protein (Tagged) is a Human Full Length protein, in the 1 to 610 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

COVA1, ENOX2, Ecto-NOX disulfide-thiol exchanger 2, APK1 antigen, Cytosolic ovarian carcinoma antigen 1, Tumor-associated hydroquinone oxidase, tNOX

1 Images
SDS-PAGE - Recombinant Human ENOX2/tNOX protein (Tagged) (AB235678)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ENOX2/tNOX protein (Tagged) (AB235678)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel of ab235678.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

Tag free

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q16206

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

Previously labelled as ENOX2.
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Sequence info

[{"sequence":"MQRDFRWLWVYEIGYAADNSRTLNVDSTAMTLPMSDPTAWATAMNNLGMAPLGIAGQPILPDFDPALGMMTGIPPITPMMPGLGIVPPPIPPDMPVVKEIIHCKSCTLFPPNPNLPPPATRERPPGCKTVFVGGLPENGTEQIIVEVFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLGSSTDKKDTGRLHVDFAQARDDLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKESCASRLCASNQDSEYPLEKTMNSSPIKSEREALLVGIISTFLHVHPFGASIEYICSYLHRLDNKICTSDVECLMGRLQHTFKQEMTGVGASLEKRWKFCGFEGLKLT","proteinLength":"Full Length","predictedMolecularWeight":"77.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":610,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q16206","tags":[]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ENOX2 also known as tumor-associated NADH oxidase or tNOX is a protein involved in cellular processes including growth and apoptosis. It has a molecular mass of approximately 46 kDa and exhibits unique activity patterns cycling with a 24-minute period. ENOX2 is expressed mostly in cancer cells but not in normal cells which makes it a potential biomarker for various types of cancer. This expression pattern offers a significant advantage for targeted cancer therapies focusing efforts on treating malignant cells while sparing healthy tissues.
Biological function summary

This enzyme plays a role in electron transport and cell surface NADH oxidase activity. ENOX2 forms part of a complex involved in the regulation of cellular energy and growth directly impacting cellular proliferation rates. It contributes to the maintenance of extracellular environments that support cancer cell survival and proliferation. Its activity parallels growth rates in cancer cells further implicating its function in tumorigenesis and oncogenic processes.

Pathways

ENOX2 operates within the NADH/NAD+ redox system and impacts the pathways that govern cellular metabolism and energy flow. It interacts with proteins in the oxidative phosphorylation pathway which is critical for ATP production and cellular energy regulation. ENOX2 links to proteins such as cytochrome c oxidase and its influence extends to pathways associated with glycolytic processes and mitochondrial function illustrating its central part in metabolic reprogramming in cancer cells.

ENOX2 is strongly associated with cancer serving as both a diagnostic marker and a potential therapeutic target. Its cancer-specific expression pattern exposes its linkage to oncogenic pathways. ENOX2 is connected to other proteins implicated in cancer such as HER2/neu playing a role in breast cancer. Additionally it relates to neurodegenerative disorders where alterations in cellular metabolism contribute to disease progression although the precise mechanisms remain under investigation.
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Specifications

Form

Liquid

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General info

Function

May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock.

Sequence similarities

Belongs to the ENOX family.

Post-translational modifications

Glycosylated.

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Product protocols

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Target data

May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock.
See full target information ENOX2
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Complementary Products

Primary Antibodies

AB210751

Anti-ENOX2/tNOX antibody

Immunocytochemistry/ Immunofluorescence - Anti-ENOX2/tNOX antibody (AB210751)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Secondary Antibodies

AB191866

VHH Single Domain Anti-Rabbit IgG Fc (HRP)

Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - VHH Single Domain Anti-Rabbit IgG Fc (HRP) (AB191866)

  • 5
  • 2
Proteins & Peptides

AB164739

Recombinant Human PAQR8 protein

SDS-PAGE - Recombinant Human PAQR8 protein (AB164739)

  • 0
  • 0

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