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Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
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Recombinant Human Entactin/NID protein is a Human Fragment protein, in the 1148 to 1247 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Wheat germ
GST tag N-Terminus
ELISA, WB
No
E G L Q Y P F A V T S Y G K N L Y F T D W K M N S V V A L D L A I S K E T D A F Q P H K Q T R L Y G I T T A L S Q C P Q G H N Y C S V N N G G C T H L C L A T P G S R T C R C P D N T L G V D C I E R K
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.
Nidogen-1, NID-1, Entactin, NID, NID1
Recombinant Human Entactin/NID protein is a Human Fragment protein, in the 1148 to 1247 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Nidogen-1, NID-1, Entactin, NID, NID1
Wheat germ
GST tag N-Terminus
ELISA, WB
No
No
Human
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
E G L Q Y P F A V T S Y G K N L Y F T D W K M N S V V A L D L A I S K E T D A F Q P H K Q T R L Y G I T T A L S Q C P Q G H N Y C S V N N G G C T H L C L A T P G S R T C R C P D N T L G V D C I E R K
Fragment
1148 to 1247
Recombinant
GST tag N-Terminus
Liquid
Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.
N- and O-glycosylated.
Dry Ice
-80°C
Upon delivery aliquot
Avoid freeze / thaw cycle
This product was previously labelled as Entactin.
Entactin interacts closely with laminin and type IV collagen within the extracellular matrix forming an important part of the basement membrane complex. This protein aids in the stabilization and linkage of these matrices playing an essential role in cellular adhesion and migration processes. By facilitating the structural assembly of basement membranes entactin supports cellular signaling pathways that are involved in tissue development and repair.
Entactin also known as nidogen-1 or NID1 is a significant glycoprotein of the extracellular matrix with a molecular mass of approximately 150 kDa. This protein is often referred to as nidogen and nidogen 1. It localizes mainly in basement membranes across various tissues. Entactin serves as an important structural component and mediator between other extracellular molecules contributing significantly to the maintenance and integrity of the basement membrane structure.
Entactin acts within the integrin signaling pathway and the basement membrane formation pathway. It interacts with integrin receptors on the cell surface thereby influencing processes like cell adhesion and morphogenesis. Through these pathways entactin signals in coordination with laminins and collagens building a robust structural framework necessary for tissue integrity and function.
Entactin's disruption has links to cancer and certain genetic disorders affecting basement membrane integrity. Aberrant expression or dysfunction of entactin can contribute to the progression of tumor invasion due to its pivotal role in cellular adhesion. Furthermore it associates with muscular dystrophies through interactions with laminins and collagens highlighting its importance in maintaining normal tissue architecture and function.
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ab158997 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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