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AB219293

Recombinant Human ENTPD3 protein (His tag)

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Recombinant Human ENTPD3 protein (His tag) is a Human Fragment protein, in the 44 to 485 aa range, expressed in Baculovirus infected insect cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

CD39L3, ENTPD3, Ectonucleoside triphosphate diphosphohydrolase 3, NTPDase 3, CD39 antigen-like 3, Ecto-ATP diphosphohydrolase 3, Ecto-apyrase 3, HB6, Ecto-ATPDase 3, Ecto-ATPase 3

1 Images
SDS-PAGE - Recombinant Human ENTPD3 protein (His tag) (AB219293)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ENTPD3 protein (His tag) (AB219293)

15% SDS-PAGE analysis of 3 μg ab219293.

Molecular Weight : 50-70 kDa (SDS-PAGE under reducing conditions).

Key facts

Purity

>90% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

Baculovirus infected insect cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

O75355

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS, 10% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"ADLQIHKQEVLPPGLKYGIVLDAGSSRTTVYVYQWPAEKENNTGVVSQTFKCSVKGSGISSYGNNPQDVPRAFEECMQKVKGQVPSHLHGSTPIHLGATAGMRLLRLQNETAANEVLESIQSYFKSQPFDFRGAQIISGQEEGVYGWITANYLMGNFLEKNLWHMWVHPHGVETTGALDLGGASTQISFVAGEKMDLNTSDIMQVSLYGYVYTLYTHSFQCYGRNEAEKKFLAMLLQNSPTKNHLTNPCYPRDYSISFTMGHVFDSLCTVDQRPESYNPNDVITFEGTGDPSLCKEKVASIFDFKACHDQETCSFDGVYQPKIKGPFVAFAGFYYTASALNLSGSFSLDTFNSSTWNFCSQNWSQLPLLLPKFDEVYARSYCFSANYIYHLFVNGYKFTEETWPQIHFEKEVGNSSIAWSLGYMLSLTNQIPAESPLIRLPIEPPHHHHHH","proteinLength":"Fragment","predictedMolecularWeight":"50.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":485,"aminoAcidStart":44,"nature":"Recombinant","expressionSystem":"Baculovirus infected insect cells","accessionNumber":"O75355","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ENTPD3 also known as NTPDase 3 an enzyme present on the cell surface functions in nucleotide metabolism by hydrolyzing ATP and ADP to AMP and inorganic phosphate. It is a member of the ectonucleoside triphosphate diphosphohydrolase family and encoded by the ENTPD3 gene. This protein has an approximate mass of 65 kDa. Expression of ENTPD3 is found in various tissues notably in the brain and pancreas contributing to its role in nucleotide regulation in these areas.
Biological function summary

ENTPD3 serves a role in the control of extracellular nucleotide levels affecting purinergic signaling. This enzyme operates as part of the broader purinergic signaling complex and plays a role in modulating the availability of nucleotides for signal transduction. ENTPD3's activity modulates neurotransmission and vascular function highlighting its importance in these biological processes within specific tissues like the nervous system and endothelial cells.

Pathways

ENTPD3 participates in the purinergic signaling pathway where it regulates extracellular levels of nucleotides influencing signaling events related to cellular communication and response. This pathway interacts closely with other proteins like P2X and P2Y receptors which are also integral to nucleotides' function as signaling molecules. ENTPD3's role in this pathway highlights its involvement in maintaining homeostasis in cellular environments.

ENTPD3 links to conditions such as neuropathic pain and diabetes. Dysregulation of purinergic signaling where ENTPD3 is an important player can contribute to abnormal cell signaling and inflammation which has been noted in neuropathic pain. Moreover its expression in the pancreas suggests a connection to insulin regulation and consequently diabetes. Interaction with other proteins such as those in the insulin signaling pathway frames ENTPD3 as a potential target in efforts to understand and treat these disorders.
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Specifications

Form

Liquid

Additional notes

Affinity purified

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General info

Function

Has a threefold preference for the hydrolysis of ATP over ADP.

Sequence similarities

Belongs to the GDA1/CD39 NTPase family.

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Product protocols

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Target data

Has a threefold preference for the hydrolysis of ATP over ADP.
See full target information ENTPD3
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