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AB183226

Recombinant Human ENTPD6 protein (denatured) (His tag N-Terminus)

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Recombinant Human ENTPD6 protein (denatured) (His tag N-Terminus) is a Human Fragment protein, in the 61 to 484 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE.

View Alternative Names

CD39L2, IL6ST2, ENTPD6, Ectonucleoside triphosphate diphosphohydrolase 6, NTPDase 6, CD39 antigen-like 2

1 Images
SDS-PAGE - Recombinant Human ENTPD6 protein (denatured) (His tag N-Terminus) (AB183226)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ENTPD6 protein (denatured) (His tag N-Terminus) (AB183226)

15% SDS-PAGE analysis of ab183226 (3μg).

Key facts

Purity

>80% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

O75354

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSKWHRATATQAFFSITRAAPGARWGQQAHSPLGTAADGHEVFYGIMFDAGSTGTRVHVFQFTRPPRETPTLTHETFKALKPGLSAYADDVEKSAQGIRELLDVAKQDIPFDFWKATPLVLKATAGLRLLPGEKAQKLLQKVKEVFKASPFLVGDDCVSIMNGTDEGVSAWITINFLTGSLKTPGGSSVGMLDLGGGSTQIAFLPRVEGTLQASPPGYLTALRMFNRTYKLYSYSYLGLGLMSARLAILGGVEGQPAKDGKELVSPCLSPSFKGEWEHAEVTYRVSGQKAAASLHELCAARVSEVLQNRVHRTEEVKHVDFYAFSYYYDLAAGVGLIDAEKGGSLVVGDFEIAAKYVCRTLETQPQSSPFSCMDLTYVSLLLQEFGFPRSKVLKLTRKIDNVETSWALGAIFHYIDSLNRQKSPAS","proteinLength":"Fragment","predictedMolecularWeight":"48.74 kDa","actualMolecularWeight":null,"aminoAcidEnd":484,"aminoAcidStart":61,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O75354","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ENTPD6 also known as ectonucleoside triphosphate diphosphohydrolase 6 is an enzyme associated with hydrolysis of nucleotides converting ATP and ADP into AMP. This enzyme has a molecular mass of approximately 50 kDa. ENTPD6 shows expression predominantly in cells involved in the immune system such as lymphocytes and macrophages. In addition ENTPD6 can also be detected in the brain suggesting a possible role in neural processes.
Biological function summary

ENTPD6 is involved in the regulation of extracellular nucleotide levels which has implications for cell signaling and immune response modulation. It is not part of complex structures but performs its activity individually. The regulation of nucleotide levels by ENTPD6 influences inflammation and platelet aggregation processes. By modulating the availability of extracellular nucleotides ENTPD6 indirectly impacts signaling pathways mediated by P2 receptors.

Pathways

ENTPD6 participates in the purinergic signaling and nucleotide metabolism pathways. In the purinergic signaling pathway it cooperates with other ectonucleotidases to maintain adenosine levels which are important for energy balance and cellular communication. ENTPD6 is functionally related to proteins such as CD39 and CD73 which also act in nucleotide hydrolysis and influence these pathways. This cooperation ensures the balanced function of extracellular signaling and immune responses.

Alteration in ENTPD6 activity has been linked to immune-related disorders and neurological conditions. Abnormal ENTPD6 expression or function can contribute to autoimmune diseases by affecting immune cell activity. It may also impact neurodegenerative diseases as its role in neural tissues suggests involvement in neuroinflammation. The interaction with proteins like CD39 and CD73 which also modulate immune responses further connects ENTPD6 to these disorders and their progression.
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Specifications

Form

Liquid

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General info

Function

Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. Has a strong preference for nucleoside diphosphates, preferentially hydrolyzes GDP, IDP, and UDP, with slower hydrolysis of CDP, ITP, GTP, CTP, ADP, and UTP and virtually no hydrolysis of ATP (PubMed : 10948193, PubMed : 11041856, PubMed : 14529283). The membrane bound form might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides (PubMed : 10948193, PubMed : 11041856, PubMed : 14529283).

Sequence similarities

Belongs to the GDA1/CD39 NTPase family.

Post-translational modifications

The secreted form may be produced by intracellular processing.. N-glycosylated.

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Product protocols

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Target data

Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. Has a strong preference for nucleoside diphosphates, preferentially hydrolyzes GDP, IDP, and UDP, with slower hydrolysis of CDP, ITP, GTP, CTP, ADP, and UTP and virtually no hydrolysis of ATP (PubMed : 10948193, PubMed : 11041856, PubMed : 14529283). The membrane bound form might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides (PubMed : 10948193, PubMed : 11041856, PubMed : 14529283).
See full target information ENTPD6
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