Recombinant Human Eotaxin protein
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Recombinant Human Eotaxin protein is a Human Full Length protein, in the 24 to 97 aa range, expressed in HEK 293 cells, with >95%, <0.005 EU/µg endotoxin level, suitable for SDS-PAGE, Mass Spec, HPLC.
View Alternative Names
SCYA11, CCL11, Eotaxin, C-C motif chemokine 11, Eosinophil chemotactic protein, Small-inducible cytokine A11
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant Human Eotaxin protein (AB282376)
Mass determination by ESI-TOF.
Predicted MW 8421.95 is Da (+/- 10 Da by ESI-TOF). Observed MW is 8421.91 Da. Additional masses at 8624.00, 8989.00 are due to residual O-glycans.
- HPLC
Supplier Data
HPLC - Recombinant Human Eotaxin protein (AB282376)
HPLC analysis of ab282376.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human Eotaxin protein (AB282376)
SDS-PAGE analysis of ab282376.
Complementary Products
Primary Antibodies
AB317281
Anti-Eotaxin antibody [EPR26619-76] - BSA and Azide free (Detector)
Recombinant|RabMAb
![Sandwich ELISA - Anti-Eotaxin antibody [EPR26619-76] - BSA and Azide free (Detector) (AB317281)](https://content.abcam.com/products/images/eotaxin-antibody-epr26619-76-bsa-and-azide-free-detector-ab317281--sandwich-elisa-img428974.jpg)
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Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Eotaxin plays an important role in immune response regulation particularly in allergic reactions. It functions by binding to CCR3 a receptor found on eosinophils therefore facilitating their migration. This process includes involvement in the formation of protein complexes that modulate cell signaling. Eotaxin's primary biological role lies in promoting the accumulation of eosinophils which are important for the immune defense against parasitic infections.
Pathways
Eotaxin participates in the MAPK/ERK signaling pathway which influences cell migration and proliferation. Additionally it operates within the NF-kB pathway often regulating inflammation and immune response. In these pathways eotaxin interacts with other proteins like CCR3 and IL-5 contributing to a coordinated response in immune signaling.
Specifications
Form
Lyophilized
Additional notes
=95% by HPLC
General info
Function
Chemokine that plays a central role in both allergic and non-allergic inflammatory reactions by inducing the migration of different leukocyte types including eosinophils, basophils, macrophages and dendritic cells (PubMed : 8597956, PubMed : 33846499). Exerts its effects primarily by binding to the CCR3 receptor (PubMed : 8631813). Induces also chemotaxis of endothelial cells and promotes angiogenesis by activating the PI3K/Akt pathway (PubMed : 28279120).
Sequence similarities
Belongs to the intercrine beta (chemokine CC) family.
Post-translational modifications
O-linked glycan consists of a Gal-GalNAc disaccharide which is modified with up to 2 sialic acid residues.
Target data
Product promise
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