Recombinant Human EPCR/CD201 protein (denatured) is a Human Fragment protein, in the 18 to 210 aa range, expressed in Escherichia coli, with >80% purity and suitable for SDS-PAGE.
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Key facts
- Purity
- >80% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S S Q D A S D G L Q R L H M L Q I S Y F R D P Y H V W Y Q G N A S L G G H L T H V L E G P D T N T T I I Q L Q P L Q E P E S W A R T Q S G L Q S Y L L Q F H G L V R L V H Q E R T L A F P L T I R C F L G C E L P P E G S R A H V F F E V A V N G S S F V S F R P E R A L W Q A D T Q V T S G V V T F T L Q Q L N A Y N R T R Y E L R E F L E D T C V Q Y V Q K H I S A E N T K G S Q T S R S Y T S
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
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Target data
Function
Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.
Alternative names
CD201, EPCR, PROCR, Endothelial protein C receptor, Activated protein C receptor, Endothelial cell protein C receptor, APC receptor
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Recombinant Human EPCR/CD201 protein (denatured) is a Human Fragment protein, in the 18 to 210 aa range, expressed in Escherichia coli, with >80% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >80% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q9UNN8-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S S Q D A S D G L Q R L H M L Q I S Y F R D P Y H V W Y Q G N A S L G G H L T H V L E G P D T N T T I I Q L Q P L Q E P E S W A R T Q S G L Q S Y L L Q F H G L V R L V H Q E R T L A F P L T I R C F L G C E L P P E G S R A H V F F E V A V N G S S F V S F R P E R A L W Q A D T Q V T S G V V T F T L Q Q L N A Y N R T R Y E L R E F L E D T C V Q Y V Q K H I S A E N T K G S Q T S R S Y T S
- Accession
- Q9UNN8
- Protein length
- Fragment
- Predicted molecular weight
- 24.4 kDa
- Amino acids
- 18 to 210
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.
- Post-translational modifications
N-glycosylated.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
EPCR also known as CD201 stands for Endothelial Protein C Receptor. It is a glycoprotein with a molecular mass of approximately 46 kDa. EPCR is expressed mainly on endothelial cells which line the interior surface of blood vessels. This receptor plays a mechanical role in binding to protein C a zymogen that is converted to activated protein C (APC) by thrombin-thrombomodulin complex. By facilitating the activation of protein C EPCR contributes to the regulation of blood coagulation and inflammation processes.
- Biological function summary
The EPCR is part of the protein C anticoagulant pathway where it acts as a cofactor. EPCR is vital in enhancing the activation of protein C on the endothelial surface reducing coagulation activity. It interacts closely with thrombomodulin and protein C to form this complex preventing excessive thrombus formation and contributing to vascular integrity. Apart from its anticoagulant role EPCR also modulates inflammatory responses supporting its function as a bridge between coagulation and inflammation.
- Pathways
EPCR lies within the protein C anticoagulation pathway and the endothelial signaling pathways. Its primary partner in the anticoagulation pathway is APC which degrades activated factors Va and VIIIa providing a check against coagulation. Additionally EPCR’s interaction with APC and thrombomodulin links this protein to the endothelial signaling pathway where it affects cell survival and inflammation regulation. This interaction is essential to maintain hemostatic balance and control vascular responses to inflammatory stimuli.
- Associated diseases and disorders
EPCR associates with conditions like thrombosis and sepsis. In thrombosis inadequate expression or function of EPCR can lead to uncontrolled blood clotting due to insufficient activation of protein C. Sepsis a severe inflammatory response to infection shows abnormal modulation of the protein C pathway where EPCR's role becomes pivotal. Additionally APC which interacts directly with EPCR is critical in the pathological states of these diseases highlighting the therapeutic potential in targeting EPCR pathway.
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1 product image
SDS-PAGE - Recombinant Human EPCR/CD201 protein (denatured) (ab180310)
15% SDS-PAGE analysis of ab180310 (3 μg).
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