Recombinant human Eph receptor A1/EphA1 protein
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Recombinant human Eph receptor A1/EphA1 protein is a Human Fragment protein, in the 613 to 892 aa range, expressed in Baculovirus infected Sf9 cells, with >95%, suitable for SDS-PAGE, FuncS.
View Alternative Names
EPH, EPHT, EPHT1, EPHA1, Ephrin type-A receptor 1, hEpha1, EPH tyrosine kinase, EPH tyrosine kinase 1, Erythropoietin-producing hepatoma receptor, Tyrosine-protein kinase receptor EPH
- FuncS
Supplier Data
Functional Studies - Recombinant human Eph receptor A1/EphA1 protein (AB206006)
The specific activity of ab206006 was determined to be 20 nmol/min/mg.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant human Eph receptor A1/EphA1 protein (AB206006)
SDS-PAGE analysis of ab206006 by densitometry, approximate MW 55 kDa.
Complementary Products
Reactivity data
Product details
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
EphA1 contributes to cellular adhesion migration and positioning linking to ephrin ligands to form signaling complexes. These complexes aid in regulating developmental processes such as angiogenesis and neuronal development by transmitting signals that control cell shape and movement. The EphA1 receptor also influences cell proliferation and plays a role in the inhibition of cell migration by responding to concentration gradients of ephrin ligands. Its ability to control cellular boundaries and morphology highlights its importance in tissue patterning and organogenesis.
Pathways
EphA1 integrates into the Eph/ephrin signaling pathway a critical framework for developmental processes and cellular organization. This pathway involves cross-talk with the MAPK signaling cascade which further influences cell proliferation and differentiation. The interplay between EphA1 and other Eph receptors like EphB2 enhances bidirectional signaling that accommodates both forward and reverse signal transduction a feature that accommodates dynamic cellular responses in development and homeostasis.
Specifications
Form
Liquid
Additional notes
Affinity purified.
General info
Function
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Also plays a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Post-translational modifications
Phosphorylated. Autophosphorylation is stimulated by its ligand EFNA1.. Ubiquitinated.
Target data
Product promise
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