Recombinant human Eph receptor B6 protein (His tag)
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Recombinant human Eph receptor B6 protein (His tag) is a Human Fragment protein, in the 1 to 579 aa range, expressed in HEK 293 cells, with >92%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS.
View Alternative Names
Ephrin type-B receptor 6, HEP, Tyrosine-protein kinase-defective receptor EPH-6, EPHB6
- FuncS
Supplier Data
Functional Studies - Recombinant human Eph receptor B6 protein (His tag) (AB276223)
Measured by its binding ability in a functional ELISA.
Immobilized recombinant human EphB6 at 10 μg/ml (100 μl/well) can bind human EphrinB1 with a linear range of 32-800 ng/ml.
- FuncS
Supplier Data
Functional Studies - Recombinant human Eph receptor B6 protein (His tag) (AB276223)
Measured by its binding ability in a functional ELISA.
Immobilized recombinant human EphB6 at 10 μg/ml (100 μl/well) can bind human EphrinB2 with a linear range of 1.28-32 ng/ml.
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant human Eph receptor B6 protein (His tag) (AB276223)
SDS-PAGE analysis of ab276223
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
EphB6 plays an important role in cell adhesion migration and regulation of immune responses. Although it forms part of the larger Eph-ephrin signaling complex EphB6 contributes to cellular communication without exhibiting intrinsic catalytic action. Its interactions often influence cytoskeletal organization and can impact cell shape and movement. More specifically EphB6 signaling is modulated through its ability to form complexes with other kinases such as EphB1 or EphB4 which can provide the kinase activity needed for downstream effects.
Pathways
EphB6 participates in important signaling networks such as the PI3K/AKT and MAPK pathways. These pathways are important for regulating cell survival and proliferation. In the context of these pathways EphB6 interacts with proteins such as PI3K influencing pathway activation and cellular outcomes. Eph-ephrin complexes can also integrate into the MAPK pathway through other Eph receptors facilitating various cellular responses in development and immune function.
Specifications
Form
Lyophilized
General info
Function
Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Post-translational modifications
Ligand-binding increases phosphorylation on tyrosine residues. Phosphorylation on tyrosine residues is mediated by transphosphorylation by the catalytically active EPHB1 in a ligand-independent manner. Tyrosine phosphorylation of the receptor may act as a switch on the functional transition from cell adhesion/attraction to de-adhesion/repulsion.
Target data
Complementary Products
Product promise
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