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Recombinant Human Ephrin A3 protein (denatured) is a Human Full Length protein, in the 23 to 214 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.

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Images

SDS-PAGE - Recombinant Human Ephrin A3 protein (denatured) (AB156351), expandable thumbnail

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

Biologically active

No

Amino acid sequence

M G S S H H H H H H S S G L V P R G S H M G S H M Q G P G G A L G N R H A V Y W N S S N Q H L R R E G Y T V Q V N V N D Y L D I Y C P H Y N S S G V G P G A G P G P G G G A E Q Y V L Y M V S R N G Y R T C N A S Q G F K R W E C N R P H A P H S P I K F S E K F Q R Y S A F S L G Y E F H A G H E Y Y Y I S T P T H N L H W K C L R M K V F V C C A S T S H S G E K P V P T L P Q F T M G P N V K I N V L E D F E G E N P Q V P K L E K S I S G

Reactivity data

Application

SDS-PAGE

Reactivity

Reacts

Dilution info

-

Notes

-

Associated Products

Select an associated product type

2 products for Alternative Product

Target data

Function

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).

Alternative names

Recommended products

Recombinant Human Ephrin A3 protein (denatured) is a Human Full Length protein, in the 23 to 214 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Applications

SDS-PAGE

Accession
P52797-1
Animal free

No

Species

Human

Concentration
Loading...
Storage buffer

pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

Sequence info

Amino acid sequence

M G S S H H H H H H S S G L V P R G S H M G S H M Q G P G G A L G N R H A V Y W N S S N Q H L R R E G Y T V Q V N V N D Y L D I Y C P H Y N S S G V G P G A G P G P G G G A E Q Y V L Y M V S R N G Y R T C N A S Q G F K R W E C N R P H A P H S P I K F S E K F Q R Y S A F S L G Y E F H A G H E Y Y Y I S T P T H N L H W K C L R M K V F V C C A S T S H S G E K P V P T L P Q F T M G P N V K I N V L E D F E G E N P Q V P K L E K S I S G

Accession

P52797

Protein length

Full Length

Predicted molecular weight

24 kDa

Amino acids

23 to 214

Nature

Recombinant

Tags

His tag N-Terminus

Specifications

Form

Liquid

General info

Function

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).

Sequence similarities

Belongs to the ephrin family.

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Ephrin A3 also known as Ephrin-A3 or EFNA3 is a member of the ephrin family that interacts with Eph receptors which are a group of tyrosine kinase receptors. Ephrin A3 has a mass of approximately 24 kDa. It is expressed in various tissues including the brain where it plays a significant role in neural development. The expression pattern of Ephrin A3 suggests its involvement in a wide range of physiological processes.

Biological function summary

Ephrin A3 acts as an important regulator in cell communication and spatial organization within the brain's neuronal network. It forms a complex with Eph receptors on adjacent cells leading to bidirectional signaling necessary for processes like axon guidance and synaptic plasticity. Ephrin A3's ability to guide axons is important for neural pathfinding during development. It also participates in the clustering of neurons required for the formation of precise neural circuits.

Pathways

Ephrin A3 is a significant player in the Eph/ephrin signaling pathway which influences the dynamics of cell adhesion shape and movement. It is closely related to EphA3 and EphA4 receptors through these pathways. The signaling influences the cytoskeleton affecting cell migration and tissue boundary formation. Additionally Ephrin A3 interacts within the Rho family of GTPase signaling pathways that regulate cytoskeletal rearrangements impacting cellular morphology and motility.

Associated diseases and disorders

Ephrin A3 is implicated in conditions like cancer and neurological disorders. Aberrant expression or signaling of Ephrin A3 contributes to tumor progression and metastasis potentially through its role in modifying cell adhesion and migration. Through its involvement in the neural network it may also relate to neurodegenerative diseases. The interaction with proteins like EphA2 in cancer highlights its potential as a therapeutic target. Understanding these interactions opens pathways for strategies to modulate its function in disease contexts.

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1 product image

  • SDS-PAGE - Recombinant Human Ephrin A3 protein (denatured) (ab156351), expandable thumbnail

    SDS-PAGE - Recombinant Human Ephrin A3 protein (denatured) (ab156351)

    15% SDS-PAGE analysis of ab156351 (3μg).

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Product protocols

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