Recombinant Human Ephrin B1 protein (Fc Chimera His Tag)
Be the first to review this product! Submit a review
|
(0 Publication)
Recombinant Human Ephrin B1 protein (Fc Chimera His Tag) is a Human Fragment protein, in the 28 to 237 aa range, expressed in Baculovirus infected insect cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.
View Alternative Names
EFL3, EPLG2, LERK2, EFNB1, Ephrin-B1, EFL-3, ELK ligand, EPH-related receptor tyrosine kinase ligand 2, ELK-L, LERK-2
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human Ephrin B1 protein (Fc Chimera His Tag) (AB235877)
15% SDS-PADE analysis of 3 μg ab235877.
50-70 kDa (Under reducing conditions)
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Ephrin-B1 is critical for cell positioning and boundary formation. It is part of a transmembrane protein complex influencing cell-to-cell interactions. Through its role in adhesion and repulsion Ephrin-B1 helps coordinate developmental processes such as tissue assembly and organ development. The protein serves essential roles in maintaining cellular architecture ensuring that cells adhere and detach properly during development and wound repair.
Pathways
The ephrin-B1 signaling is important to the Eph receptor pathways particularly the EphB forward and reverse signaling pathways. These pathways are well known for their functions in axon guidance and synaptic plasticity linking Ephrin-B1 with the nervous system development. Related proteins in these pathways include EphB2 and EphB4 which work alongside Ephrin-B1 in regulating the dynamics of these pathways facilitating processes like neurite outgrowth and spine morphogenesis.
Specifications
Form
Liquid
Additional notes
Affinity purified
General info
Function
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development (PubMed : 7973638, PubMed : 8070404). Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells (PubMed : 7973638, PubMed : 8070404). Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (PubMed : 7973638, PubMed : 8070404). Can also bind EPHB2 and EPHB3 (PubMed : 8070404). Binds to, and induces collapse of, commissural axons/growth cones in vitro (By similarity). May play a role in constraining the orientation of longitudinally projecting axons (By similarity).
Sequence similarities
Belongs to the ephrin family.
Post-translational modifications
Inducible phosphorylation of tyrosine residues in the cytoplasmic domain.. Proteolytically processed. The ectodomain is cleaved, probably by a metalloprotease, to produce a membrane-tethered C-terminal fragment. This fragment is then further processed by the gamma-secretase complex to yield a soluble intracellular domain peptide which can translocate to the nucleus. The intracellular domain peptide is highly labile suggesting that it is targeted for degradation by the proteasome.
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com