Recombinant Human Ephrin B3 protein (His tag)
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Recombinant Human Ephrin B3 protein (His tag) is a Human Fragment protein, in the 28 to 226 aa range, expressed in Baculovirus infected insect cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.
View Alternative Names
EPLG8, LERK8, EFNB3, Ephrin-B3, EPH-related receptor transmembrane ligand ELK-L3, EPH-related receptor tyrosine kinase ligand 8, LERK-8
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human Ephrin B3 protein (His tag) (AB219452)
15% SDS-PAGE using 3ug of ab219452.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
EFNB3 influences axon guidance and neural development. As part of a receptor-ligand complex it interacts with Eph receptors to regulate synaptic plasticity which is essential for learning and memory. This interaction also plays a role in mediating repulsive and attractive signals that guide neurons during developmental processes. EFNB3 exhibits distinct binding characteristics which determine specific cellular responses.
Pathways
EFNB3 influences both the ephrin signaling pathway and the nervous system development pathway. It engages with Eph receptors particularly EphB3 and EphA4 to trigger downstream signaling cascades that influence cellular structure and fate. The Eph-ephrin pathways are important in neurodevelopmental processes assisting in the formation of spatially regulated cell organization.
Specifications
Form
Liquid
Additional notes
Affinity purified
General info
Function
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity).. (Microbial infection) Acts as a receptor for nipah virus and hendra virus.
Sequence similarities
Belongs to the ephrin family.
Target data
Complementary Products
Product promise
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