Recombinant human Epigen protein (Active)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Epigen protein also referred to by its gene name EPGN is a member of the epidermal growth factor (EGF) family. This protein has a molecular mass of approximately 19 kDa and is known for being expressed in several tissues with notable expression in the liver and heart. Its structure includes a single EGF-like domain that plays a role in its functional interaction with other cellular components.

Biological function summary

Epigen is involved in promoting cell proliferation and differentiation. It interacts with the epidermal growth factor receptor (EGFR) triggering downstream signaling pathways that influence cell growth. While Epigen acts independently it may have interactions that suggest participation in broader molecular complexes. These interactions contribute to its role in various physiological processes such as tissue repair and maintenance.

Pathways

Epigen engages in the EGFR signaling pathway an essential mechanism for regulating cell division and survival. This pathway includes proteins such as EGFR and its downstream effectors like the MAPK and PI3K pathways. Through these pathways Epigen influences cellular responses to growth signals effectively linking extracellular cues to intracellular actions.

Epigen is associated with cancer and cardiovascular diseases. Abnormal expression or activity of Epigen can lead to enhanced cell proliferation a hallmark of oncogenesis. Its interaction with proteins like EGFR has been implicated in tumor progression and metastasis. In cardiovascular conditions Epigen’s regulatory role on cardiac cells ties it to disorders where cell proliferation is disrupted or improperly controlled.