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AB276595

Recombinant Human Epiphycan protein (His tag)

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Recombinant Human Epiphycan protein (His tag) is a Human Full Length protein, in the 1 to 322 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

DSPG3, PGLB, SLRR3B, EPYC, Epiphycan, Dermatan sulfate proteoglycan 3, Proteoglycan-Lb, Small chondroitin/dermatan sulfate proteoglycan, PG-Lb

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SDS-PAGE - Recombinant Human Epiphycan protein (His tag) (AB276595)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Epiphycan protein (His tag) (AB276595)

SDS-PAGE analysis of ab276595

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q99645

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MKTLAGLVLGLVIFDAAVTAPTLESINYDSETYDATLEDLDNLYNYENIPVDKVEIEIATVMPSGNRELLTPPPQPEKAQEEEEEEESTPRLIDGSSPQEPEFTGVLGPHTNEDFPTCLLCTCISTTVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPELPTTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNPINLSKTPQAYMCLPRLPVGSLV","proteinLength":"Full Length","predictedMolecularWeight":"36.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":322,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q99645","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Epiphycan also known as DSPG3 is a small leucine-rich proteoglycan with an approximate mass of 38 kDa. Epiphycan appears mainly in cartilage and the eye. It functions mechanically by interacting with collagen fibers and other components in the extracellular matrix. This interaction helps in regulating collagen fibril assembly and spacing important for maintaining tissue integrity and function.
Biological function summary

The protein plays a part in maintaining the structural integrity and resilience of connective tissues. Although Epiphycan is not part of a larger complex it works closely with other extracellular matrix molecules contributing to tissue elasticity and hydration. This role is significant in tissues such as cartilage where mechanical stress is persistent and its efficient functionality is necessary.

Pathways

This protein takes part in the assembly and organization of the extracellular matrix. It participates significantly in the collagen fibril organization pathway. This pathway involves interactions with proteins such as decorin and biglycan which are also part of the small leucine-rich proteoglycan family. These interactions are essential for maintaining the ordered arrangement of collagen fibrils in connective tissues.

Mutations or dysregulation of Epiphycan relate to skeletal dysplasias and osteoarthritis. In osteoarthritis the altered interactions within the extracellular matrix contribute to cartilage degradation and joint dysfunction. The protein's connection with decorin becomes relevant here as both engage in maintaining matrix homeostasis. Understanding these interactions helps reveal potential therapeutic targets to address these conditions.
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Specifications

Form

Lyophilized

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General info

Function

May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization.

Sequence similarities

Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.

Post-translational modifications

The O-linked polysaccharides on Thr-60 and Ser-96 are probably the mucin type linked to GalNAc. There is one glycosaminoglycan chain, known to be dermatan sulfate, and it is probably the O-glycosylation at Ser-64.

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Product protocols

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Target data

May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization.
See full target information EPYC
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Complementary Products

Primary Antibodies

AB122449

Anti-Epiphycan antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Epiphycan antibody (AB122449)

  • 0
  • 0
Primary Antibodies

AB171978

Anti-TIMMDC1/C3orf1 antibody [EPR11807]

RabMAb|Recombinant

Western blot - Anti-TIMMDC1/C3orf1 antibody [EPR11807] (AB171978)

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  • 0
Proteins & Peptides

AB276760

Recombinant Mouse MD1 protein (His tag)

SDS-PAGE - Recombinant Mouse MD1 protein (His tag) (AB276760)

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  • 0
Primary Antibodies

AB28179

Anti-TFIIF antibody

ChIP - Anti-TFIIF antibody (AB28179)

  • 5
  • 2

Product promise

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