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AB162865

Recombinant Human EPS8L1 protein (GST tag N-Terminus)

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Recombinant Human EPS8L1 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 551 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

DRC3, EPS8R1, PP10566, EPS8L1, Epidermal growth factor receptor kinase substrate 8-like protein 1, EPS8-like protein 1, Epidermal growth factor receptor pathway substrate 8-related protein 1, EPS8-related protein 1

1 Images
SDS-PAGE - Recombinant Human EPS8L1 protein (GST tag N-Terminus) (AB162865)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human EPS8L1 protein (GST tag N-Terminus) (AB162865)

ab162865 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q8TE68

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGRKAIVLAIANTSLAFPLCQHLVTFCLGEDDGVHTVEDASRKLAVMDSQGRVWAQEMLLRVSPDHVTLLDPASKEELESYPLGAIVRCDAVMPPGRSRSLLLLVCQEPERAQPDVHFFQGLRLGAELIREDIQGALHNYRSGRGERRAAALRATQEELQRDRSPAAETPPLQRRPSVRAVISTVERGAGRGRPQAKPIPEAEEAQRPEPVGTSSNADSASPDLGPRGPDLAVLQAEREVDILNHVFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAGEGLLTLRAKPPSEAEYTDVLQKIKYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTSGGPEFASSVRRPHLTSDAVALLRDNVTPRENELWTSLGDSWTRPGLELSPEEGPPYRPEFFSGWEPPVTDPQSRAWEDPVEKQLQHERRRRQVTQATQQGRGWEVRGRGRSAWPRLTRLSYFLQQSAPQVAVNGHRDLEPESEPQLESETAGKWVLCNYDFQARNSSELSVKQRDVLEVLEDKEKVSELEAVMEKQKKKVEGEVEMEVI","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":551,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q8TE68","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

EPS8L1 also known as Epidermal Growth Factor Receptor Pathway Substrate 8-Like Protein 1 is a protein that weighs approximately 82 kDa. This protein is a member of the EPS8 family known for its capacity to modulate signaling pathways related to cell growth and differentiation. EPS8L1 exhibits expression in various tissues but shows significant expression in epithelial tissues. It plays a mechanical role in linking receptor tyrosine kinases to downstream signaling cascades.
Biological function summary

EPS8L1 contributes to the regulation of actin cytoskeleton dynamics. This protein forms part of a complex with other scaffold proteins impacting cell migration and adhesion processes. Through this role EPS8L1 influences cellular shape and motility which affects tissue organization and repair. Its function in modulating actin structure makes it an important player in maintaining proper cellular architecture.

Pathways

EPS8L1 participates in the EGFR signaling pathway where it acts to mediate the effects of growth factors on cellular mechanics. This pathway includes the interactions of EPS8L1 with proteins such as EGF receptor and SOS1 connecting extracellular signals to intracellular responses that drive proliferation and survival. Additionally EPS8L1 operates within the MAPK/ERK pathway further linking it to cellular growth and differentiation stimuli by interacting with Ras family proteins.

Alterations in EPS8L1 function and expression have associations with cancerous developments particularly involving epithelial-derived tumors. Its interactions with the EGFR and other related receptor proteins contribute to tumor progression and metastasis. Additionally EPS8L1's role in cytoskeletal regulation links it to neurodegenerative diseases where impaired cellular architecture affects neuronal survival and function. These associations highlight the importance of EPS8L1 in maintaining cellular homeostasis and its potential as a therapeutic target.
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Specifications

Form

Liquid

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General info

Function

Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton.

Sequence similarities

Belongs to the EPS8 family.

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Product protocols

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Target data

Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton.
See full target information EPS8L1
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