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AB132633

Recombinant Human EPS8L2 protein (GST tag N-Terminus)

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Recombinant Human EPS8L2 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 715 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

EPS8R2, PP13181, EPS8L2, Epidermal growth factor receptor kinase substrate 8-like protein 2, EPS8-like protein 2, Epidermal growth factor receptor pathway substrate 8-related protein 2, EPS8-related protein 2

1 Images
SDS-PAGE - Recombinant Human EPS8L2 protein (GST tag N-Terminus) (AB132633)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human EPS8L2 protein (GST tag N-Terminus) (AB132633)

12.5% SDS-PAGE analysis of ab132633 stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

SDS-PAGE, WB, ELISA

applications

Biologically active

No

Accession

Q9H6S3

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.32% Glutathione

storage-buffer

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Complementary Products

Proteins & Peptides

AB162865

Recombinant Human EPS8L1 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human EPS8L1 protein (GST tag N-Terminus) (AB162865)

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  • 0
Primary Antibodies

AB126155

Anti-EPS8L2 antibody

Western blot - Anti-EPS8L2 antibody (AB126155)

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  • 1
Cell Lines & Lysates

AB258412

Human EPS8L2 knockout HeLa cell lysate

Sanger Sequencing - Human EPS8L2 knockout HeLa cell lysate (AB258412)

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  • 0
Cell Lines & Lysates

AB265785

Human EPS8L2 knockout HeLa cell line

Sanger Sequencing - Human EPS8L2 knockout HeLa cell line (AB265785)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MSQSGAVSCCPGATNGSLGRSDGVAKMSPKDLFEQRKKYSNSNVIMHETSQYHVQHLATFIMDKSEAITSVDDAIRKLVQLSSKEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTVQRSQTVLNQLRYPSVLLLVCQDSEQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKMRPQTLKGHQEKIRQRQSILPPPQGPAPIPFQHRGGDSPEAKNRVGPQVPLSEPGFRRRESQEEPRAVLAQKIEKETQILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEGVLTLRARPPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDIARSVSCPLLSRDAVDFLRGHLVPKEMSLWESLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPVDVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPVSSPHTHRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVPCNILGEARPEDAGAPFEQAGQKYWGPASPTHKLPPSFPGNKDELMQHMDEVNDELIRKISNIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIVENLGILTGPQLFSLNKEELKKVCGEEGVRVYSQLTMQKAFLEKQQSGSELEELMNKFHSMNQRRGEDS","proteinLength":"Full Length","predictedMolecularWeight":"107 kDa","actualMolecularWeight":null,"aminoAcidEnd":715,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9H6S3","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

EPS8L2 also known as Epidermal Growth Factor Receptor Substrate 8-Like Protein 2 plays a mechanical role in cellular signaling and cytoskeletal organization. This protein has a molecular mass of approximately 97 kDa. EPS8L2 expresses in various tissues including the brain liver and testis where it contributes to diverse cellular processes. Its structural components include actin-binding domains which allow interaction with the cytoskeleton and other signaling molecules.
Biological function summary

EPS8L2 regulates actin cytoskeleton dynamics and signal transduction pathways. It is part of the EPS8 family of proteins and functions within a complex to mediate cell shape and movement. This protein acts as a scaffold that facilitates interactions among actin filaments and other proteins which influences cell migration and invasion. EPS8L2 modifies actin-related changes that are essential in dynamic cellular environments.

Pathways

EPS8L2 integrates into the EGFR (Epidermal Growth Factor Receptor) signaling pathway influencing cellular growth and differentiation. In another role it participates in the MAPK/ERK pathway by interacting with components like GRB2 and SOS1. These pathways control various aspects of cell behavior impacting cell proliferation and survival. Related proteins such as EPS8 also share similar pathway interactions and have overlapping functions in cellular signaling.

EPS8L2 connects to cancer and neurodegenerative diseases. In cancer dysregulation of EGFR signaling involving EPS8L2 may contribute to tumor progression and metastasis. The protein's interactions influence cellular behaviors critical to cancer development. In neurodegenerative disorders alterations in cytoskeletal dynamics associated with EPS8L2 may exacerbate conditions like Alzheimer's Disease. This protein interacts with others like ApoE impacting pathways linked to neuronal health and degeneration.
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Specifications

Form

Liquid

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General info

Function

Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity).

Sequence similarities

Belongs to the EPS8 family.

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Product protocols

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Target data

Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity).
See full target information EPS8L2
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Product promise

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