Recombinant Human epsilon Tubulin protein is a Human Full Length protein, in the 1 to 475 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Images
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M T Q S V V V Q V G Q C G N Q I G C C F W D L A L R E H A A V N Q K G I Y D E A I S S F F R N V D T R V V G D G G S I S K G K I C S L K A R A V L I D M E E G V V N E I L Q G P L R D V F D T K Q L I T D I S G S G N N W A V G H K V F G S L Y Q D Q I L E K F R K S A E H C D C L Q C F F I I H S M G G G T G S G L G T F L L K V L E D E F P E V Y R F V T S I Y P S G E D D V I T S P Y N S I L A M K E L N E H A D C V L P I D N Q S L F D I I S K I D L M V N S G K L G T T V K P K S L V T S S S G A L K K Q H K K P F D A M N N I V A N L L L N L T S S A R F E G S L N M D L N E I S M N L V P F P Q L H Y L V S S L T P L Y T L T D V N I P P R R L D Q M F S D A F S K D H Q L L R A D P K H S L Y L A C A L M V R G N V Q I S D L R R N I E R L K P S L Q F V S W N Q E G W K T S L C S V P P V G H S H S L L A L A N N T C V K P T F M E L K E R F M R L Y K K K A H L H H Y L Q V E G M E E S C F T E A V S S L S A L I Q E Y D Q L D A T K N M P V Q D L P R L S I A M
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Alternative names
TUBE, TUBE1, Tubulin epsilon chain, Epsilon-tubulin
Recommended products
Recombinant Human epsilon Tubulin protein is a Human Full Length protein, in the 1 to 475 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- Q9UJT0-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M T Q S V V V Q V G Q C G N Q I G C C F W D L A L R E H A A V N Q K G I Y D E A I S S F F R N V D T R V V G D G G S I S K G K I C S L K A R A V L I D M E E G V V N E I L Q G P L R D V F D T K Q L I T D I S G S G N N W A V G H K V F G S L Y Q D Q I L E K F R K S A E H C D C L Q C F F I I H S M G G G T G S G L G T F L L K V L E D E F P E V Y R F V T S I Y P S G E D D V I T S P Y N S I L A M K E L N E H A D C V L P I D N Q S L F D I I S K I D L M V N S G K L G T T V K P K S L V T S S S G A L K K Q H K K P F D A M N N I V A N L L L N L T S S A R F E G S L N M D L N E I S M N L V P F P Q L H Y L V S S L T P L Y T L T D V N I P P R R L D Q M F S D A F S K D H Q L L R A D P K H S L Y L A C A L M V R G N V Q I S D L R R N I E R L K P S L Q F V S W N Q E G W K T S L C S V P P V G H S H S L L A L A N N T C V K P T F M E L K E R F M R L Y K K K A H L H H Y L Q V E G M E E S C F T E A V S S L S A L I Q E Y D Q L D A T K N M P V Q D L P R L S I A M
- Accession
- Q9UJT0
- Protein length
- Full Length
- Amino acids
- 1 to 475
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Sequence similarities
Belongs to the tubulin family.
- Subcellular localisation
- Cytoskeleton, Microtubule organizing center, Centrosome
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Epsilon tubulin also known as TUBE1 is part of the tubulin family of proteins involved in microtubule formation. It has a molecular mass of approximately 55 kDa. Epsilon tubulin localizes primarily to centrioles structures located at the core of centrosomes the key organizers of microtubules in cells. Epsilon tubulin expression occurs in tissues with high cell division activity such as in embryonic and tumor cells where centriole replication is essential.
- Biological function summary
Epsilon tubulin plays a role in the assembly and stabilization of microtubules. It is part of the centriolar complex which is involved in the nucleation and anchoring of microtubules at the centrosome. This function is important for maintaining cell polarity motility and intracellular transport. During cell division epsilon tubulin assists in forming the mitotic spindle ensuring chromosomes are properly segregated.
- Pathways
Microtubule dynamics and organization involve epsilon tubulin as an integral part of centrosome maturation and spindle assembly pathways. It interacts with other tubulin isotypes like alpha and beta tubulin to facilitate the polymerization of tubulin dimers essential for microtubule stability and growth. Epsilon tubulin's function connects to the regulatory systems controlling cell cycle progression ensuring proper cell division and the prevention of aneuploidy.
- Associated diseases and disorders
Abnormalities in epsilon tubulin expression or function relate to conditions such as cancer and ciliopathies. In cancer disrupted microtubule dynamics and spindle assembly may involve epsilon tubulin dysregulation leading to genomic instability and tumor progression. Similarly its altered function could connect with disorders involving the primary cilium such as polycystic kidney disease where defective microtubule anchoring and centrosome function play a role.
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1 product image
SDS-PAGE - Recombinant Human epsilon Tubulin protein (ab162445)
ab162445 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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Product protocols
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