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AB162445

Recombinant Human epsilon Tubulin protein (GST tag N-Terminus)

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Recombinant Human epsilon Tubulin protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 475 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

TUBE, TUBE1, Tubulin epsilon chain, Epsilon-tubulin

1 Images
SDS-PAGE - Recombinant Human epsilon Tubulin protein (GST tag N-Terminus) (AB162445)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human epsilon Tubulin protein (GST tag N-Terminus) (AB162445)

ab162445 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q9UJT0

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MTQSVVVQVGQCGNQIGCCFWDLALREHAAVNQKGIYDEAISSFFRNVDTRVVGDGGSISKGKICSLKARAVLIDMEEGVVNEILQGPLRDVFDTKQLITDISGSGNNWAVGHKVFGSLYQDQILEKFRKSAEHCDCLQCFFIIHSMGGGTGSGLGTFLLKVLEDEFPEVYRFVTSIYPSGEDDVITSPYNSILAMKELNEHADCVLPIDNQSLFDIISKIDLMVNSGKLGTTVKPKSLVTSSSGALKKQHKKPFDAMNNIVANLLLNLTSSARFEGSLNMDLNEISMNLVPFPQLHYLVSSLTPLYTLTDVNIPPRRLDQMFSDAFSKDHQLLRADPKHSLYLACALMVRGNVQISDLRRNIERLKPSLQFVSWNQEGWKTSLCSVPPVGHSHSLLALANNTCVKPTFMELKERFMRLYKKKAHLHHYLQVEGMEESCFTEAVSSLSALIQEYDQLDATKNMPVQDLPRLSIAM","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":475,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9UJT0","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Epsilon tubulin also known as TUBE1 is part of the tubulin family of proteins involved in microtubule formation. It has a molecular mass of approximately 55 kDa. Epsilon tubulin localizes primarily to centrioles structures located at the core of centrosomes the key organizers of microtubules in cells. Epsilon tubulin expression occurs in tissues with high cell division activity such as in embryonic and tumor cells where centriole replication is essential.
Biological function summary

Epsilon tubulin plays a role in the assembly and stabilization of microtubules. It is part of the centriolar complex which is involved in the nucleation and anchoring of microtubules at the centrosome. This function is important for maintaining cell polarity motility and intracellular transport. During cell division epsilon tubulin assists in forming the mitotic spindle ensuring chromosomes are properly segregated.

Pathways

Microtubule dynamics and organization involve epsilon tubulin as an integral part of centrosome maturation and spindle assembly pathways. It interacts with other tubulin isotypes like alpha and beta tubulin to facilitate the polymerization of tubulin dimers essential for microtubule stability and growth. Epsilon tubulin's function connects to the regulatory systems controlling cell cycle progression ensuring proper cell division and the prevention of aneuploidy.

Abnormalities in epsilon tubulin expression or function relate to conditions such as cancer and ciliopathies. In cancer disrupted microtubule dynamics and spindle assembly may involve epsilon tubulin dysregulation leading to genomic instability and tumor progression. Similarly its altered function could connect with disorders involving the primary cilium such as polycystic kidney disease where defective microtubule anchoring and centrosome function play a role.
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Specifications

Form

Liquid

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General info

Sequence similarities

Belongs to the tubulin family.

Subcellular localisation

Cytoskeleton

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Product protocols

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Target data

See full target information TUBE1
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