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AB202224

Recombinant Human ERGIC3 protein

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Recombinant Human ERGIC3 protein is a Human Fragment protein, in the 47 to 341 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

C20orf47, ERV46, SDBCAG84, CGI-54, PRO0989, ERGIC3, Endoplasmic reticulum-Golgi intermediate compartment protein 3, Serologically defined breast cancer antigen NY-BR-84

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SDS-PAGE - Recombinant Human ERGIC3 protein (AB202224)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ERGIC3 protein (AB202224)

15% SDS PAGE analysis of ab202224 (3μg).

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q9Y282

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 89% PBS, 10% Glycerol (glycerin, glycerine), 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSQYYLTTEVHPELYVDKSRGDKLKINIDVLFPHMPCAYLSIDAMDVAGEQQLDVEHNLFKQRLDKDGIPVSSEAERHELGKVEVTVFDPDSLDPDRCESCYGAEAEDIKCCNTCEDVREAYRRRGWAFKNPDTIEQCRREGFSQKMQEQKNEGCQVYGFLEVNKVAGNFHFAPGKSFQQSHVHVHDLQSFGLDNINMTHYIQHLSFGEDYPGIVNPLDHTNVTAPQASMMFQYFVKVVPTVYMKVDGEVLRTNQFSVTRHEKVANGLLGDQGLPGVFVLYELSPMMVKLTEKHRSF","proteinLength":"Fragment","predictedMolecularWeight":"36.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":341,"aminoAcidStart":47,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9Y282","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The ERGIC3 protein also known as ERGIC-53 plays a critical role in the early secretory pathway. It is involved in vesicular trafficking between the endoplasmic reticulum and the Golgi apparatus. Weighing around 38 kDa ERGIC3 is an important contributor to cargo transport processes. The protein finds expression in various tissues predominantly within cells that have high secretory demands.
Biological function summary

The ERGIC3 protein functions as part of the larger ER-Golgi intermediate compartment (ERGIC) complex helping in the sorting and transport of proteins. The ERGIC serves as an essential hub in the secretory pathway modulating cargo movement to the Golgi for further processing. Some studies have implicated ERGIC3 in maintaining Golgi integrity and optimal function affecting overall cellular health.

Pathways

ERGIC3 plays a significant role in the secretory pathway assisting in the transit of proteins and the correct folding of polypeptides. It links functionally to other key proteins such as KI67 which associates with cell proliferation regions and relies heavily on efficient protein processing for cellular division. The association suggests ERGIC3’s involvement in maintaining cellular growth and regeneration.

Researchers have connected ERGIC3 with diseases like congenital disorders of glycosylation due to its role in protein folding and trafficking. Furthermore disruptions in ERGIC3 function have correlations with cancer progression particularly in overactive secretion conditions. These disorders often coincide with aberrant expression or mutations in folding-related proteins signifying potential ERGIC3 involvement in pathological manifestations when its function is compromised.
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Specifications

Form

Liquid

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General info

Function

Possible role in transport between endoplasmic reticulum and Golgi. Positively regulates trafficking of the secretory proteins SERPINA1/alpha1-antitrypsin and HP/haptoglobin (PubMed : 31142615).

Sequence similarities

Belongs to the ERGIC family.

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Product protocols

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Target data

Possible role in transport between endoplasmic reticulum and Golgi. Positively regulates trafficking of the secretory proteins SERPINA1/alpha1-antitrypsin and HP/haptoglobin (PubMed : 31142615).
See full target information ERGIC3
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Complementary Products

Primary Antibodies

AB129179

Anti-ERGIC3 antibody [EPR8141]

RabMAb|Recombinant|KO Validated

Western blot - Anti-ERGIC3 antibody [EPR8141] (AB129179)

  • 5
  • 1
Cell Lines & Lysates

AB257941

Human ERGIC3 knockout HEK-293T cell lysate

Western blot - Human ERGIC3 knockout HEK-293T cell lysate (AB257941)

  • 0
  • 0
Cell Lines & Lysates

AB266489

Human ERGIC3 knockout HEK-293T cell line

Advanced Validation

Western blot - Human ERGIC3 knockout HEK-293T cell line (AB266489)

  • 0
  • 0

Product promise

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