Recombinant Human ERH protein is a Human Full Length protein, in the 1 to 104 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
>95% SDS-PAGE
- Expression system
Escherichia coli
- Tags
His tag N-Terminus
- Applications
SDS-PAGE, MS
- Biologically active
No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S M S H T I L L V Q P T K R P E G R T Y A D Y E S V N E C M E G V C K M Y E E H L K R M N P N S P S I T Y D I S Q L F D F I D D L A D L S C L V Y R A D T Q T Y Q P Y N K D W I K E K I Y V L L R R Q A Q Q A G K
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Alternative names
Enhancer of rudimentary homolog, ERH
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Recombinant Human ERH protein is a Human Full Length protein, in the 1 to 104 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
>95% SDS-PAGE
- Expression system
Escherichia coli
- Tags
His tag N-Terminus
- Applications
SDS-PAGE, MS
- Biologically active
No
- Accession
- P84090-1
- Animal free
No
- Species
Human
- Concentration
- Storage buffer
pH: 8
Constituents: 20% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl
Sequence info
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S M S H T I L L V Q P T K R P E G R T Y A D Y E S V N E C M E G V C K M Y E E H L K R M N P N S P S I T Y D I S Q L F D F I D D L A D L S C L V Y R A D T Q T Y Q P Y N K D W I K E K I Y V L L R R Q A Q Q A G K
- Accession
- P84090
- Protein length
Full Length
- Predicted molecular weight
14.6 kDa
- Amino acids
1 to 104
- Nature
Recombinant
- Tags
His tag N-Terminus
Specifications
- Form
Liquid
- Additional notes
ab104674 is purified using conventional chromatography techniques.
General info
- Function
May have a role in the cell cycle.
- Sequence similarities
Belongs to the E(R) family.
- Subcellular localisation
Nucleus
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage conditions
-20°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
ERH short for Enhancer of Rudimentary Homolog is a small protein involved in transcriptional processes. Also known in scientific literature by its alias 'e 'r 'h ' it has a molecular weight of approximately 12 kDa. ERH is widely expressed in various tissues indicating its broad role in cellular function. The protein contains two conserved domains that contribute to its ability to interact with other proteins in cellular processes.
- Biological function summary
ERH participates in transcription and RNA processing functions through its involvement with RNA binding. ERH forms part of a multi-protein complex that includes other components such as mRNA splicing factors. Its role is essential in ensuring the proper processing of precursor mRNA molecules into mature mRNAs. Such molecular functions highlight ERH's importance in maintaining the efficiency of transcription and post-transcriptional modifications.
- Pathways
Researchers have observed ERH's participation in gene expression and cell cycle pathways. Within these pathways ERH interacts with proteins like DIDO1 and SMARCA4 which are linked to chromatin remodeling and mRNA splicing respectively. The coordination of these proteins with ERH amplifies its significance in regulating gene expression and ensuring proper cell cycle progression.
- Associated diseases and disorders
ERH has connections to cancer and neurodevelopmental disorders. Alterations in ERH expression levels are associated with malignancies where its interaction with proteins such as LSF1 and SETDB1 can contribute to tumorigenesis. Similarly the disruption of ERH function links to neurodevelopmental disorders potentially through aberrant mRNA processing and gene expression regulation. These associations underline ERH as an important target for studying therapeutic interventions in these diseases.
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1 product image
SDS-PAGE - Recombinant Human ERH protein (ab104674)
15% SDS-PAGE analysis of 3μg ab104674.
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