Recombinant Human ERH protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ERH short for Enhancer of Rudimentary Homolog is a small protein involved in transcriptional processes. Also known in scientific literature by its alias 'e 'r 'h ' it has a molecular weight of approximately 12 kDa. ERH is widely expressed in various tissues indicating its broad role in cellular function. The protein contains two conserved domains that contribute to its ability to interact with other proteins in cellular processes.

Biological function summary

ERH participates in transcription and RNA processing functions through its involvement with RNA binding. ERH forms part of a multi-protein complex that includes other components such as mRNA splicing factors. Its role is essential in ensuring the proper processing of precursor mRNA molecules into mature mRNAs. Such molecular functions highlight ERH's importance in maintaining the efficiency of transcription and post-transcriptional modifications.

Pathways

Researchers have observed ERH's participation in gene expression and cell cycle pathways. Within these pathways ERH interacts with proteins like DIDO1 and SMARCA4 which are linked to chromatin remodeling and mRNA splicing respectively. The coordination of these proteins with ERH amplifies its significance in regulating gene expression and ensuring proper cell cycle progression.

ERH has connections to cancer and neurodevelopmental disorders. Alterations in ERH expression levels are associated with malignancies where its interaction with proteins such as LSF1 and SETDB1 can contribute to tumorigenesis. Similarly the disruption of ERH function links to neurodevelopmental disorders potentially through aberrant mRNA processing and gene expression regulation. These associations underline ERH as an important target for studying therapeutic interventions in these diseases.