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AB185592

Recombinant Human ERM / Etv5 protein (Tagged)

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Recombinant Human ERM / Etv5 protein (Tagged) is a Human Full Length protein, in the 1 to 510 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

ERM, ETV5, ETS translocation variant 5, Ets-related protein ERM

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

Tag free

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P41161

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MASMTGGQQMGRGHHHHHHENLYFQGGEFDGFYDQQVPFMVPGKSRSEECRGRPVIDRKRKFLDTDLAHDSEELFQDLSQLQEAWLAEAQVPDDEQFVPDFQSDNLVLHAPPPTKIKRELHSPSSELSSCSHEQALGANYGEKCLYNYCAYDRKPPSGFKPLTPPTTPLSPTHQNPLFPPPQATLPTSGHAPAAGPVQGVGPAPAPHSLPEPGPQQQTFAVPRPPHQPLQMPKMMPENQYPSEQRFQRQLSEPCHPFPPQPGVPGDNRPSYHRQMSEPIVPAAPPPPQGFKQEYHDPLYEHGVPGMPGPPAHGFQSPMGIKQEPRDYCVDSEVPNCQSSYMRGGYFSSSHEGFSYEKDPRLYFDDTCVVPERLEGKVKQEPTMYREGPPYQRRGSLQLWQFLVTLLDDPANAHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPDALFSMAFPDNQRPFLKAESECHLSEEDTLPLTHFEDSPAYLLDMDRCSSLPYAEGFAY","proteinLength":"Full Length","predictedMolecularWeight":"61 kDa","actualMolecularWeight":null,"aminoAcidEnd":510,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P41161","tags":[]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The ERM (Etv5) protein also known as ERM products or ERM Boston in some contexts functions as a transcription factor within the ETS family of proteins. This protein has a molecular weight of approximately 57 kDa. Expressed in a variety of tissues including the brain and reproductive organs Etv5 plays an important role in regulating gene expression by binding to specific DNA sequences. Its activities involve promoting transcription of genes vital for development and cellular differentiation.
Biological function summary

The ERM (Etv5) protein influences numerous developmental processes and cellular states. It participates in the MAP kinase signaling cascade where it facilitates responses to growth factors. By serving as a component in several regulatory complexes Etv5 modulates the expression of genes that control cell proliferation and survival. This activity is important for tissue development and maintenance especially in stem and progenitor cells.

Pathways

The ERM (Etv5) protein interacts with MAPK and PI3K/AKT signaling pathways essential for cellular growth and survival. These pathways often connect to the regulation of cell cycle and apoptosis involving proteins like Bcl-2 and c-Jun. Etv5 helps mediate the cellular response to external stimuli via these pathways influencing both proliferation and differentiation.

Irregular expression of the ERM (Etv5) protein correlates with conditions such as cancer and infertility. Overexpression or mutations in Etv5 have been linked to various cancers including prostate cancer where its interaction with proteins like PTEN influences tumor growth and progression. In reproductive disorders Etv5 plays a role in testicular germ cell development with disruptions potentially leading to infertility.
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Specifications

Form

Liquid

Additional notes

ab185592 was refolded using a unique temperature shift inclusion body refolding technology and chromatographically purified.

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General info

Function

Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'.

Sequence similarities

Belongs to the ETS family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'.
See full target information ETV5
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