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AB128439

Recombinant Human ERp18 protein (DDDDK tag N-Terminus + His tag N-Terminus)

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Recombinant Human ERp18 protein (DDDDK tag N-Terminus + His tag N-Terminus) is a Human Full Length protein, in the 27 to 172 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

TLP19, UNQ713/PRO1376, TXNDC12, Thioredoxin domain-containing protein 12, Endoplasmic reticulum resident protein 18, Endoplasmic reticulum resident protein 19, Thioredoxin-like protein p19, hTLP19, ER protein 18, ERp18, ER protein 19, ERp19

1 Images
SDS-PAGE - Recombinant Human ERp18 protein (DDDDK tag N-Terminus + His tag N-Terminus) (AB128439)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human ERp18 protein (DDDDK tag N-Terminus + His tag N-Terminus) (AB128439)

15% SDS-PAGE analysis of 3μg ab128439.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

DDDDK tag N-Terminus His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

O95881

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as ERp19.
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Sequence info

[{"sequence":"MRGSHHHHHHGMASMTGGQQMGRDLYDDDDKDRWGSHMHNGLGKGFGDHIHWRTLEDGKKEAAASGLPLMVIIHKSWCGACKALKPKFAESTEISELSHNFVMVNLEDEEEPKDEDFSPDGGYIPRILFLDPSGKVHPEIINENGNPSYKYFYVSAEQVVQGMKEAQERLTGDAFRKKHLEDEL","proteinLength":"Full Length","predictedMolecularWeight":"20.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":172,"aminoAcidStart":27,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O95881","tags":[{"tag":"DDDDK","terminus":"N-Terminus"},{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ERp18 also known as PDIA6 or Protein Disulfide Isomerase Family A Member 6 is an endoplasmic reticulum (ER) resident protein with a molecular mass of approximately 18 kDa. This protein is known to act as a chaperone and assists in protein folding by catalyzing disulfide bond formation. ERp18 is widely expressed in various tissues particularly in those with high protein synthesis demands such as the liver and pancreas. It localizes mainly within the lumen of the ER.
Biological function summary

ERp18 plays a role in maintaining protein homeostasis. As a member of the protein disulfide isomerase (PDI) family it is involved in the formation and rearrangement of disulfide bonds essential for proper protein architecture. ERp18 functions collaboratively with other PDIs in the ER suggesting it may be part of a larger protein complex. The efficient folding and structural stabilization of proteins are critical for cellular function and survival.

Pathways

ERp18 contributes significantly to the protein-folding pathway and is linked to the unfolded protein response (UPR). The protein is instrumental in mitigating ER stress conditions which arise when there is an accumulation of misfolded proteins. By interacting with other PDI family proteins like PDI itself and ERp72 ERp18 ensures proteins achieve correct configurations which is necessary for maintaining cellular equilibrium and preventing apoptosis.

The malfunction or dysregulation of ERp18 associates with certain neurodegenerative diseases such as Alzheimer's disease where protein misfolding plays an important role. Moreover it has connections to cancer where the proliferation of cells often correlates with increased protein synthesis and folding demands. ERp18 interacts with proteins involved in these diseases like amyloid precursor protein (APP) in Alzheimer's and HIF-1α in cancer highlighting its importance in disease contexts.
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Specifications

Form

Liquid

Additional notes

ab128439 was purified using conventional chromatography.

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General info

Function

Protein-disulfide reductase of the endoplasmic reticulum that promotes disulfide bond formation in client proteins through its thiol-disulfide oxidase activity.

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Product protocols

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Target data

Protein-disulfide reductase of the endoplasmic reticulum that promotes disulfide bond formation in client proteins through its thiol-disulfide oxidase activity.
See full target information TXNDC12
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Complementary Products

Primary Antibodies

AB134938

Anti-ERp18 antibody [EPR9024]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-ERp18 antibody [EPR9024] (AB134938)

  • 0
  • 0
Primary Antibodies

AB13506

Anti-ERp57 antibody [MaP.Erp57]

KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-ERp57 antibody [MaP.Erp57] (AB13506)

  • 5
  • 7
Secondary Antibodies

AB150113

Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (AB150113)

  • 5
  • 15
Primary Antibodies

AB121414

Anti-TMX3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMX3 antibody (AB121414)

  • 0
  • 0

Product promise

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