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AB276221

Recombinant Human ESAM protein (His tag)

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Recombinant Human ESAM protein (His tag) is a Human Fragment protein, in the 1 to 248 aa range, expressed in HEK 293 cells, with >97%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

UNQ220/PRO246, ESAM, Endothelial cell-selective adhesion molecule

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SDS-PAGE - Recombinant Human ESAM protein (His tag) (AB276221)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ESAM protein (His tag) (AB276221)

SDS-PAGE analysis of ab276221

Key facts

Purity

>97% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q96AP7

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MISLPGPLVTNLLRFLFLGLSALAPPSRAQLQLHLPANRLQAVEGGEVVLPAWYTLHGEVSSSQPWEVPFVMWFFKQKEKEDQVLSYINGVTTSKPGVSLVYSMPSRNLSLRLEGLQEKDSGPYSCSVNVQDKQGKSRGHSIKTLELNVLVPPAPPSCRLQGVPHVGANVTLSCQSPRSKPAVQYQWDRQLPSFQTFFAPALDVIRGSLSLTNLSSSMAGVYVCKAHNEVGTAQCNVTLEVSTGPGAA","proteinLength":"Fragment","predictedMolecularWeight":"25.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":248,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q96AP7","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ESAM also known as Endothelial Cell-Selective Adhesion Molecule is part of the immunoglobulin superfamily and is typically found on the surface of endothelial cells. It has a mass of roughly 44 kDa. The ESAM protein is expressed predominantly in vascular and lymphatic endothelial cells but can also be found in platelets. ESAM is important for cell adhesion playing a role in maintaining cell junctions. Through interaction with other proteins ESAM contributes to the structural integrity of blood vessels.
Biological function summary

ESAM influences vascular stability and permeability. It participates in the formation of endothelial tight junctions being an important component of cell junction complexes. In endothelial cells ESAM enhances barrier function impacting the movement of molecules and cells between the bloodstream and surrounding tissues. Its expression is essential for the organization of other junctional proteins such as claudins and occludins indicating a synergistic role within cell junctions.

Pathways

The ESAM protein is involved in the regulation of vascular integrity and immune response pathways. Particularly it interacts with signaling components of the vascular endothelial growth factor (VEGF) pathway which is important in angiogenesis. Additionally ESAM modulates the activation of PI3K/Akt signaling promoting cell survival and proliferation. Through its associations ESAM works alongside other proteins such as VE-cadherin highlighting its integrative role in vascular function.

ESAM has shown a connection to cancer progression and inflammatory diseases. In tumors aberrant ESAM expression correlates with increased tumor angiogenesis and metastasis partly due to its influence on endothelial cell permeability and migration. ESAM also relates to atherosclerosis interacting with proteins like ICAM-1 which are involved in leukocyte adhesion and vascular inflammation. Understanding its expression and function in these conditions can help in developing targeted therapies.
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Specifications

Form

Lyophilized

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General info

Function

Can mediate aggregation most likely through a homophilic molecular interaction.

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Product protocols

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Target data

Can mediate aggregation most likely through a homophilic molecular interaction.
See full target information ESAM
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