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AB129132

Recombinant Human ESM1 protein

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Recombinant Human ESM1 protein is a Human Fragment protein, in the 20 to 184 aa range, expressed in Insect cells, with >95%, suitable for SDS-PAGE.

View Alternative Names

Endothelial cell-specific molecule 1, ESM-1, ESM1

1 Images
SDS-PAGE - Recombinant Human ESM1 protein (AB129132)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ESM1 protein (AB129132)

SDS-PAGE of recombinant human ESM1 fragment (ab129132). The sample was loaded in 15% SDS-polyacrylamide gel under non-reducing conditions and stained with Coomassie blue.

Key facts

Purity

>95% SDS-PAGE

Expression system

Insect cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9NQ30

Animal free

No

Carrier free

No

Species

Human

Reconstitution

reconstitute with 50 mM acetic acid at 0.1mg/mL

Storage buffer

Constituents: 1.75% Sodium chloride, 0.71% Sodium phosphate

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"WSNNYAVDCPQHCDSSECKSSPRCKRTVLDDCGCCRVCAAGRGETCYRTVSGMDGMKCGPGLRCQPSNGEDPFGEEFGICKDCPYGTFGMDCRETCNCQSGICDRGTGCLKFPFFQYSVTKSSNRFVSLTEHDMASGDGNIVREEVVKENAAGSPVMRKWLNPRTRHHHHHH","proteinLength":"Fragment","predictedMolecularWeight":"19.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":184,"aminoAcidStart":20,"nature":"Recombinant","expressionSystem":"Insect cells","accessionNumber":"Q9NQ30","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Endothelial cell-specific molecule 1 (ESM1) also known as endocan is a proteoglycan with a mass of approximately 50 kDa. It is primarily expressed in endothelial cells of blood vessels particularly in the lungs and the kidneys. ESM1 consists of a core protein covalently attached to dermatan sulfate chains. Its expression often increases under inflammatory conditions which highlights its role in vascular biology.
Biological function summary

ESM1 acts in the regulation of cell adhesion and migration processes. It interacts with leukocytes and participates in modulating inflammatory responses. ESM1 does not form part of a multi-protein complex but its activity can influence the behavior of other cell surface molecules and receptors. This function positions ESM1 as a critical player in the dynamics of vascular endothelium.

Pathways

ESM1 modulates inflammation and angiogenesis by participating in pathways involving vascular endothelial growth factor (VEGF). It interacts with proteins such as VEGF receptor-2 impacting endothelial permeability and new blood vessel formation. These interactions situate ESM1 within the signaling networks that regulate endothelial function and vascular homeostasis.

Research associates ESM1 with conditions such as sepsis and cancer. High levels of this molecule correlate with poor prognosis in these diseases linking it functionally to VEGF and other factors involved in abnormal endothelial cell activity. Understanding ESM1's role provides insights into mechanisms of disease progression and potential therapeutic targets.
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Specifications

Form

Lyophilized

Additional notes

Affinity purified.

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General info

Function

Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions.

Post-translational modifications

May contain intrachain disulfide bonds.. O-glycosylated; contains chondroitin sulfate and dermatan sulfate.

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Product protocols

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Target data

Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions.
See full target information Endothelial cell-specific molecule 1
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