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AB152371

Recombinant Human Estrogen Related Receptor gamma protein

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(1 Publication)

Recombinant Human Estrogen Related Receptor gamma protein is a Human Full Length protein, in the 1 to 435 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

ERR3, ERRG2, KIAA0832, NR3B3, ESRRG, Estrogen-related receptor gamma, ERR gamma-2, Estrogen receptor-related protein 3, Nuclear receptor subfamily 3 group B member 3

1 Images
SDS-PAGE - Recombinant Human Estrogen Related Receptor gamma protein (AB152371)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Estrogen Related Receptor gamma protein (AB152371)

12.5% SDS-PAGE analysis of ab152371 stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB, SDS-PAGE

applications

Biologically active

No

Accession

P62508

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV","proteinLength":"Full Length","predictedMolecularWeight":"75 kDa","actualMolecularWeight":null,"aminoAcidEnd":435,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P62508","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Estrogen Related Receptor gamma (ERRγ) also known as NR3B3 is a nuclear receptor that functions as a transcription factor. This protein regulates gene expression by binding to specific DNA sequences. ERRγ has a mass of approximately 51 kDa. It is expressed in various tissues including the heart skeletal muscle brain kidney and liver. As an orphan receptor ERRγ does not have a known endogenous ligand which impacts how it responds to different cellular signals.
Biological function summary

ERRγ influences several important physiological processes. This receptor is involved in energy metabolism mitochondrial biogenesis and cellular differentiation. ERRγ often operates as part of a larger transcriptional regulatory complex interacting with co-regulators such as PGC-1α to modulate its activity. By binding to specific genes ERRγ modulates processes like glucose metabolism fatty acid oxidation and oxidative phosphorylation which are vital for cellular energy homeostasis.

Pathways

ERRγ plays a significant role in the regulation of energy homeostasis and mitochondrial function. It is an important player in the PGC-1α signaling pathway influencing the expression of genes involved in mitochondrial biogenesis and respiration. ERRγ interacts closely with Peroxisome Proliferator-Activated Receptor (PPAR) pathways enhancing the transcription of genes required for fatty acid metabolism. These interactions contribute to the adaptive response of cells to changes in energy demands and nutrient availability.

ERRγ associates with metabolic conditions and neurodegenerative diseases. Abnormal ERRγ activity has links to metabolic syndrome which includes obesity and diabetes highlighting its role in energy metabolism and insulin sensitivity. Additionally ERRγ expression changes in neurodegenerative disorders like Alzheimer's disease where it interacts with proteins like PGC-1α and influences neuronal survival and function. Understanding these associations might offer new therapeutic targets for managing these diseases.
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Specifications

Form

Liquid

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General info

Function

Orphan receptor that acts as a transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). Induces the expression of PERM1 in the skeletal muscle.

Sequence similarities

Belongs to the nuclear hormone receptor family. NR3 subfamily.

Post-translational modifications

Acetylated by PCAF/KAT2 (in vitro).. Sumoylation on Lys-40 is enhanced by phosphorylation at Ser-45 and represses transcriptional activity.. Phosphorylation on Ser-45 enhances sumoylation on Lys-40 thus repressing transcriptional activity.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Orphan receptor that acts as a transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). Induces the expression of PERM1 in the skeletal muscle.
See full target information ESRRG
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Vaccines 8: PubMed32046307

2020

A Novel Combined Scientific and Artistic Approach for the Advanced Characterization of Interactomes: The Akirin/Subolesin Model.

Applications

Unspecified application

Species

Unspecified reactive species

Sara Artigas-Jerónimo,Juan J Pastor Comín,Margarita Villar,Marinela Contreras,Pilar Alberdi,Israel León Viera,Leandro Soto,Raúl Cordero,James J Valdés,Alejandro Cabezas-Cruz,Agustín Estrada-Peña,José de la Fuente
View all publications
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