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AB180351

Recombinant Human ETS2 protein - BSA and Azide free (denatured) (His tag N-Terminus)

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Recombinant Human ETS2 protein - BSA and Azide free (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 469 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

Protein C-ets-2, ETS2

1 Images
SDS-PAGE - Recombinant Human ETS2 protein - BSA and Azide free (denatured) (His tag N-Terminus) (AB180351)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ETS2 protein - BSA and Azide free (denatured) (His tag N-Terminus) (AB180351)

3ug by SDS-PAGE under reducing conditions and visualized by coomassie blue stain.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P15036

Animal free

No

Carrier free

Yes

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Primary Antibodies

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Primary Antibodies

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Primary Antibodies

AB23698

Anti-EDG2 /LPA-1 antibody

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMNDFGIKNMDQVAPVANSYRGTLKRQPAFDTFDGSLFAVFPSLNEEQTLQEVPTGLDSISHDSANCELPLLTPCSKAVMSQALKATFSGFKKEQRRLGIPKNPWLWSEQQVCQWLLWATNEFSLVNVNLQRFGMNGQMLCNLGKERFLELAPDFVGDILWEHLEQMIKENQEKTEDQYEENSHLTSVPHWINSNTLGFGTEQAPYGMQTQNYPKGGLLDSMCPASTPSVLSSEQEFQMFPKSRLSSVSVTYCSVSQDFPGSNLNLLTNNSGTPKDHDSPENGADSFESSDSLLQSWNSQSSLLDVQRVPSFESFEDDCSQSLCLNKPTMSFKDYIQERSDPVEQGKPVIPAAVLAGFTGSGPIQLWQFLLELLSDKSCQSFISWTGDGWEFKLADPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTSGKRYVYRFVCDLQNLLGFTPEELHAILGVQPDTED","proteinLength":"Full Length","predictedMolecularWeight":"55.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":469,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P15036","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ETS2 protein or E26 transformation-specific sequence 2 is a transcription factor that is part of the ETS family. This protein is about 56 kDa in mass. It regulates gene expression by binding to specific DNA sequences. ETS2 is widely expressed in various tissues including the heart brain and liver. It influences multiple cellular processes like development proliferation and apoptosis.
Biological function summary

ETS2 protein functions in the regulation of genes that control critical cellular activities. The protein can form complexes with other transcription factors to modulate gene expression. It can interact with other proteins to influence cellular responses to external signals. As a transcription factor ETS2 also has a role in cellular differentiation and morphogenesis contributing to the development of multicellular organisms.

Pathways

ETS2 protein is involved in key signaling pathways such as the MAPK/ERK pathway and PI3K/AKT pathway. These pathways play essential roles in cell cycle regulation apoptosis and cell growth. ETS2 interacts with proteins like MAPK and AKT to transmit signals from the cell membrane to the nucleus. These interactions help coordinate responses to growth factors and stress signals influencing cellular outcomes.

The ETS2 protein has been linked to cancer and Down syndrome. In cancer dysregulation of ETS2 can lead to abnormal cell proliferation and resistance to apoptosis contributing to tumor development. In Down syndrome an extra copy of the ETS2 gene on chromosome 21 may affect normal development and contribute to associated phenotypes. ETS2's interaction with proteins like MYC and RAS can exacerbate these conditions influencing disease progression and outcomes.
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Specifications

Form

Liquid

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General info

Function

Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.

Sequence similarities

Belongs to the ETS family.

Post-translational modifications

Phosphorylation by CDK10 at Ser-220 and Ser-225 creates a phosphodegron that targets ETS2 for proteasomal degradation.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.
See full target information Protein C-ets-2
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