Recombinant Human EVI2A protein (Fc Chimera)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

EVI2A also known as Ecotropic Viral Integration Site 2A is a protein encoded by the EVI2A gene. The protein's mass is approximately 31 kilodaltons and it is commonly expressed in hematopoietic cells. EVI2A is a transmembrane protein that localizes to the endoplasmic reticulum and the Golgi apparatus. It functions in cell signaling and communication by interacting with other proteins through its transmembrane domain.

Biological function summary

The EVI2A protein plays a role in the immune system and cellular regulation. It may be part of a larger protein complex involved in the regulation of hematopoietic stem cell differentiation. EVI2A is implicated in cell growth signaling pathways where it assists in transmitting signals that can affect cellular fate decisions. The protein's localization and function suggest an involvement in cellular developmental processes important for immune responses.

Pathways

The role of EVI2A involves participation in the hematopoietic stem cell differentiation pathway as well as the Notch signaling pathway. These pathways are significant for the development and function of the immune system. Within these pathways EVI2A interacts with other proteins like NOTCH1 and JAGGED1 which regulate cell fate and differentiation. EVI2A's involvement highlights its contribution to the regulation of these critical biological processes.

EVI2A links to diseases such as leukemia and DiGeorge syndrome. In leukemia the protein's dysregulation can result in the uncontrolled proliferation of hematopoietic cells. EVI2A's connection in DiGeorge syndrome may involve its interaction with the NOTCH1 protein which can lead to developmental defects in the thymus and other organs. These associations suggest EVI2A as a potential target for understanding and treating related disorders.