Recombinant Human EWI-2 protein (His tag)
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Recombinant Human EWI-2 protein (His tag) is a Human Fragment protein, in the 28 to 579 aa range, expressed in Baculovirus infected insect cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.
View Alternative Names
CD316, CD81P3, EWI2, KCT4, IGSF8, Immunoglobulin superfamily member 8, IgSF8, CD81 partner 3, Glu-Trp-Ile EWI motif-containing protein 2, Keratinocytes-associated transmembrane protein 4, LIR-D1, Prostaglandin regulatory-like protein, EWI-2, KCT-4, PGRL
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human EWI-2 protein (His tag) (AB222989)
3 μg ab222989 analyzed by 15% SDS-PAGE.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
EWI-2 influences several cellular processes including adhesion and migration. It is part of a complex with other tetraspanin proteins such as CD81 and CD9 which form tetraspanin-enriched microdomains on the cell membrane. These microdomains contribute to the regulation of signal transduction pathways associated with immune responses and tissue repair.
Pathways
EWI-2 interacts with several proteins to modulate biological responses. It is involved in the integrin signaling pathway where it can associate with the β1 integrin influencing cell adhesion and migration. Additionally EWI-2 participates in the tetraspanin web impacting the organization of proteins like CD81 and CD9 which play roles in cell communication and immune regulation.
Specifications
Form
Liquid
Additional notes
Affinity purified
General info
Function
Member of the immunoglobulin superfamily (IgSF) that links tetraspanin-enriched microdomains to the actin cytoskeleton and plays several important roles in innate and adaptive immunity (PubMed : 11504738, PubMed : 14662754). Acts as an inducible receptor of HSPA8 on dendritic cells to enhance the CCL21/SLC-dependent migration of activated mature dendritic cells while attenuating their antigen-specific stimulatory capacities (PubMed : 17785435). In complex with alpha-actinins ACTN1 and ACTN4, regulates actin dynamics in the immune synapse and subsequent T-cell activation (PubMed : 22689882). Inhibits the entry of several viruses such as hepatitis C Virus (HCV) or HIV-1. Mechanistically, promotes a change in CD81 organization at the plasma membrane by significantly restricting its diffusion which in turn influences CD81 interaction with Claudin-1/CLDN1, preventing CLDN1 from acting as a co-receptor required for HCV entry (PubMed : 23351194). Accumulates at the presynaptic terminal, the producer cell side of the virological synapse, to prevent HIV-1 Env-mediated cell-cell fusion (PubMed : 31757023). Highly expressed on malignant cells with antigen presentation defects, interacts with NK receptor KIR3DL2 to suppress NK-cell cytotoxicity (PubMed : 38657602). May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.
Target data
Complementary Products
Product promise
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