Recombinant Human EXOSC8 protein
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Recombinant Human EXOSC8 protein is a Human Full Length protein, in the 1 to 276 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
OIP2, RRP43, EXOSC8, Exosome complex component RRP43, Exosome component 8, Opa-interacting protein 2, Ribosomal RNA-processing protein 43, p9, OIP-2
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human EXOSC8 protein (AB180278)
15% SDS-PAGE analysis of ab180278 (3μg).
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
EXOSC8 plays a central role in RNA metabolism as part of the exosome complex which is essential for RNA processing and turnover. It assists in the degradation of both precursor mRNA and aberrantly processed RNA. The exosome complex typically includes nine core components with EXOSC8 acting alongside these to help maintain RNA stability and facilitate gene expression regulation.
Pathways
EXOSC8 is involved in RNA processing pathways essential for cellular function and survival. These pathways such as the RNA degradation pathway and mRNA surveillance pathway ensure the quality and regulation of RNA species. EXOSC8 interacts closely with other exosome components like EXOSC3 and EXOSC9 enhancing RNA degradation and contributing to cellular homeostasis.
Specifications
Form
Liquid
Additional notes
ab180278 is purified using conventional chromatography.
General info
Function
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs.
Sequence similarities
Belongs to the RNase PH family.
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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