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AB165703

Recombinant Human FAAH2 protein

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Recombinant Human FAAH2 protein is a Human Full Length protein, in the 1 to 532 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

AMDD, FAAH2, Fatty-acid amide hydrolase 2, Amidase domain-containing protein, Anandamide amidohydrolase 2, Oleamide hydrolase 2

1 Images
SDS-PAGE - Recombinant Human FAAH2 protein (AB165703)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human FAAH2 protein (AB165703)

ab165703 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q6GMR7

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MAPSFTARIQLFLLRALGFLIGLVGRAALVLGGPKFASKTPRPVTEPLLLLSGMQLAKLIRQRKVKCIDVVQAYINRIKDVNPMINGIVKYRFEEAMKEAHAVDQKLAEKQEDEATLENKWPFLGVPLTVKEAFQLQGMPNSSGLMNRRDAIAKTDATVVALLKGAGAIPLGITNCSELCMWYESSNKIYGRSNNPYDLQHIVGGSSGGEGCTLAAACSVIGVGSDIGGSIRMPAFFNGIFGHKPSPGVVPNKGQFPLAVGAQELFLCTGPMCRYAEDLAPMLKVMAGPGIKRLKLDTKVHLKDLKFYWMEHDGGSFLMSKVDQDLIMTQKKVVVHLETILGASVQHVKLKKMKYSFQLWIAMMSAKGHDGKEPVKFVDLLGDHGKHVSPLWELIKWCLGLSVYTIPSIGLALLEEKLRYSNEKYQKFKAVEESLRKELVDMLGDDGVFLYPSHPTVAPKHHVPLTRPFNFAYTGVFSALGLPVTQCPLGLNAKGLPLGIQVVAGPFNDHLTLAVAQYLEKTFGGWVCPGKF","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":532,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q6GMR7","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FAAH2 (Fatty Acid Amide Hydrolase 2) is an enzyme that breaks down fatty acid amides. FAAH2 shows structural similarity to FAAH but has distinct substrate specificity. The approximate molecular mass of FAAH2 is 63 kDa. It is widely expressed in several human tissues including the brain liver and kidneys among others. Understanding FAAH2's mechanical role can offer insights into its biological functions and applications in research.
Biological function summary

FAAH2 acts in regulating lipid signaling pathways by hydrolyzing bioactive fatty acid amides. Unlike FAAH FAAH2 appears less efficient in degrading some endocannabinoids suggesting a unique role in signaling processes. It does not function as part of a larger protein complex but its activity results in bioactive lipids important for various cellular responses. This regulation helps maintain cellular lipid balance and influences cellular communication.

Pathways

FAAH2 participates in the endocannabinoid and lipid signaling pathways. It helps modulate local levels of fatty acid amides affecting synaptic plasticity and pain perception. FAAH2 is related to proteins like FAAH through shared involvement in these pathways which manage neurotransmitter release and reception. Understanding FAAH2's placement and function within these pathways can help in designing new therapeutic approaches.

FAAH2 shows potential links to neurological conditions and metabolic disorders. Altered FAAH2 activity may contribute to mood disorders due to its role in endocannabinoid regulation. FAAH2 also has a potential relationship with obesity where altered lipid signaling disrupts energy balance. FAAH closely associated with FAAH2 might share overlapping physiological roles that could influence disease outcomes when FAAH2 function is disrupted. Research into the links of FAAH2 with disorders provides avenues for targeted therapies.
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Specifications

Form

Liquid

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General info

Function

Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed : 17015445, PubMed : 19926788). Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates.

Sequence similarities

Belongs to the amidase family.

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Product protocols

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Target data

Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed : 17015445, PubMed : 19926788). Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates.
See full target information FAAH2
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