Recombinant Human FAAH2 protein is a Human Full Length protein, in the 1 to 532 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Images
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M A P S F T A R I Q L F L L R A L G F L I G L V G R A A L V L G G P K F A S K T P R P V T E P L L L L S G M Q L A K L I R Q R K V K C I D V V Q A Y I N R I K D V N P M I N G I V K Y R F E E A M K E A H A V D Q K L A E K Q E D E A T L E N K W P F L G V P L T V K E A F Q L Q G M P N S S G L M N R R D A I A K T D A T V V A L L K G A G A I P L G I T N C S E L C M W Y E S S N K I Y G R S N N P Y D L Q H I V G G S S G G E G C T L A A A C S V I G V G S D I G G S I R M P A F F N G I F G H K P S P G V V P N K G Q F P L A V G A Q E L F L C T G P M C R Y A E D L A P M L K V M A G P G I K R L K L D T K V H L K D L K F Y W M E H D G G S F L M S K V D Q D L I M T Q K K V V V H L E T I L G A S V Q H V K L K K M K Y S F Q L W I A M M S A K G H D G K E P V K F V D L L G D H G K H V S P L W E L I K W C L G L S V Y T I P S I G L A L L E E K L R Y S N E K Y Q K F K A V E E S L R K E L V D M L G D D G V F L Y P S H P T V A P K H H V P L T R P F N F A Y T G V F S A L G L P V T Q C P L G L N A K G L P L G I Q V V A G P F N D H L T L A V A Q Y L E K T F G G W V C P G K F
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
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Target data
Function
Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:17015445, PubMed:19926788). Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates.
Alternative names
AMDD, FAAH2, Fatty-acid amide hydrolase 2, Amidase domain-containing protein, Anandamide amidohydrolase 2, Oleamide hydrolase 2
Recommended products
Recombinant Human FAAH2 protein is a Human Full Length protein, in the 1 to 532 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- Q6GMR7-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M A P S F T A R I Q L F L L R A L G F L I G L V G R A A L V L G G P K F A S K T P R P V T E P L L L L S G M Q L A K L I R Q R K V K C I D V V Q A Y I N R I K D V N P M I N G I V K Y R F E E A M K E A H A V D Q K L A E K Q E D E A T L E N K W P F L G V P L T V K E A F Q L Q G M P N S S G L M N R R D A I A K T D A T V V A L L K G A G A I P L G I T N C S E L C M W Y E S S N K I Y G R S N N P Y D L Q H I V G G S S G G E G C T L A A A C S V I G V G S D I G G S I R M P A F F N G I F G H K P S P G V V P N K G Q F P L A V G A Q E L F L C T G P M C R Y A E D L A P M L K V M A G P G I K R L K L D T K V H L K D L K F Y W M E H D G G S F L M S K V D Q D L I M T Q K K V V V H L E T I L G A S V Q H V K L K K M K Y S F Q L W I A M M S A K G H D G K E P V K F V D L L G D H G K H V S P L W E L I K W C L G L S V Y T I P S I G L A L L E E K L R Y S N E K Y Q K F K A V E E S L R K E L V D M L G D D G V F L Y P S H P T V A P K H H V P L T R P F N F A Y T G V F S A L G L P V T Q C P L G L N A K G L P L G I Q V V A G P F N D H L T L A V A Q Y L E K T F G G W V C P G K F
- Accession
- Q6GMR7
- Protein length
- Full Length
- Amino acids
- 1 to 532
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:17015445, PubMed:19926788). Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates.
- Sequence similarities
Belongs to the amidase family.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
FAAH2 (Fatty Acid Amide Hydrolase 2) is an enzyme that breaks down fatty acid amides. FAAH2 shows structural similarity to FAAH but has distinct substrate specificity. The approximate molecular mass of FAAH2 is 63 kDa. It is widely expressed in several human tissues including the brain liver and kidneys among others. Understanding FAAH2's mechanical role can offer insights into its biological functions and applications in research.
- Biological function summary
FAAH2 acts in regulating lipid signaling pathways by hydrolyzing bioactive fatty acid amides. Unlike FAAH FAAH2 appears less efficient in degrading some endocannabinoids suggesting a unique role in signaling processes. It does not function as part of a larger protein complex but its activity results in bioactive lipids important for various cellular responses. This regulation helps maintain cellular lipid balance and influences cellular communication.
- Pathways
FAAH2 participates in the endocannabinoid and lipid signaling pathways. It helps modulate local levels of fatty acid amides affecting synaptic plasticity and pain perception. FAAH2 is related to proteins like FAAH through shared involvement in these pathways which manage neurotransmitter release and reception. Understanding FAAH2's placement and function within these pathways can help in designing new therapeutic approaches.
- Associated diseases and disorders
FAAH2 shows potential links to neurological conditions and metabolic disorders. Altered FAAH2 activity may contribute to mood disorders due to its role in endocannabinoid regulation. FAAH2 also has a potential relationship with obesity where altered lipid signaling disrupts energy balance. FAAH closely associated with FAAH2 might share overlapping physiological roles that could influence disease outcomes when FAAH2 function is disrupted. Research into the links of FAAH2 with disorders provides avenues for targeted therapies.
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1 product image
SDS-PAGE - Recombinant Human FAAH2 protein (ab165703)
ab165703 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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