Recombinant Human FAAH2 protein (denatured)
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Recombinant Human FAAH2 protein (denatured) is a Human Fragment protein, in the 32 to 532 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE.
View Alternative Names
AMDD, FAAH2, Fatty-acid amide hydrolase 2, Amidase domain-containing protein, Anandamide amidohydrolase 2, Oleamide hydrolase 2
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human FAAH2 protein (denatured) (AB174403)
15% SDS-PAGE analysis of 3μg ab174403.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
FAAH2 acts in regulating lipid signaling pathways by hydrolyzing bioactive fatty acid amides. Unlike FAAH FAAH2 appears less efficient in degrading some endocannabinoids suggesting a unique role in signaling processes. It does not function as part of a larger protein complex but its activity results in bioactive lipids important for various cellular responses. This regulation helps maintain cellular lipid balance and influences cellular communication.
Pathways
FAAH2 participates in the endocannabinoid and lipid signaling pathways. It helps modulate local levels of fatty acid amides affecting synaptic plasticity and pain perception. FAAH2 is related to proteins like FAAH through shared involvement in these pathways which manage neurotransmitter release and reception. Understanding FAAH2's placement and function within these pathways can help in designing new therapeutic approaches.
Specifications
Form
Liquid
General info
Function
Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed : 17015445, PubMed : 19926788). Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates.
Sequence similarities
Belongs to the amidase family.
Target data
Complementary Products
Product promise
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