Recombinant Human FABP6 protein is a Human Full Length protein, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE.
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Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- Tag free
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M A F T G K F E M E S E K N Y D E F M K L L G I S S D V I E K A H N F K I V T E V Q Q D G Q D F T W S Q H Y Y G G H T M T N K F T V G K E S N I Q T M G G K T F K A T V Q M E G G K L V V N F P N Y H Q T S E I V G D K L V E V S T I G G V T Y E R V S K R L A
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity). In vitro binds to bile acids in the order: deoxycholic acid > cholic acid > chenodeoxycholic acid and respective BA conjugation modifies affinities in the order taurine-conjugated > glycine-conjugated > unconjugated bile acids. Stimulates gastric acid and pepsinogen secretion (By similarity). Isoform 2. Essential for the survival of colon cancer cells to bile acid-induced apoptosis.
Alternative names
ILBP, ILLBP, FABP6, Gastrotropin, GT, Fatty acid-binding protein 6, Ileal lipid-binding protein, Intestinal 15 kDa protein, Intestinal bile acid-binding protein, I-15P, I-BABP
Recommended products
Recombinant Human FABP6 protein is a Human Full Length protein, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- Tag free
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- P51161-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: PBS, 10% Glycerol (glycerin, glycerine)
Sequence info
Amino acid sequence
- M A F T G K F E M E S E K N Y D E F M K L L G I S S D V I E K A H N F K I V T E V Q Q D G Q D F T W S Q H Y Y G G H T M T N K F T V G K E S N I Q T M G G K T F K A T V Q M E G G K L V V N F P N Y H Q T S E I V G D K L V E V S T I G G V T Y E R V S K R L A
- Accession
- P51161
- Protein length
- Full Length
- Nature
- Recombinant
Specifications
- Form
- Liquid
- Additional notes
Purified by using conventional chromatography techniques.
General info
- Function
Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity). In vitro binds to bile acids in the order: deoxycholic acid > cholic acid > chenodeoxycholic acid and respective BA conjugation modifies affinities in the order taurine-conjugated > glycine-conjugated > unconjugated bile acids. Stimulates gastric acid and pepsinogen secretion (By similarity).
- Sequence similarities
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
Notes
ab87381 corresponds to isoform 2, 128 aas.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Fatty acid-binding protein 6 (FABP6) also known as ileal bile acid binding protein (IBABP) plays a significant role in binding bile acids. This protein weighs approximately 14 kDa and is prominently expressed in the ileum of the small intestine. It functions primarily within the cytoplasm ensuring the transportation of bile acids to specific locations within cells. By doing this FABP6 facilitates the proper metabolism and absorption of these acids which are critical components for the digestion and absorption of dietary fats.
- Biological function summary
The protein plays a critical role in the enterohepatic circulation of bile acids which it binds with high affinity. FABP6 operates within a network of ligands and ions aiding in the homeostasis of bile acids. While it does not directly associate with larger complexes its action contributes to maintaining a balance of cholesterol and fats in the body. It also integrates with other fatty acid-binding proteins like FABP1 and FABP3 which engage in similar transport functions in different tissues.
- Pathways
FABP6 functions prominently within the bile acid signaling and lipid metabolism pathways. It interacts closely with proteins such as FXR (Farnesoid X receptor) that senses bile acid concentrations and regulates their synthesis and transport. Additionally FABP6 has relationship with the bile acid-CoA:amino acid N-acyltransferase (BAAT) which is involved in bile acid conjugation. These connections underpin its key role in lipid digestion and cholesterol homeostasis.
- Associated diseases and disorders
FABP6 has associations with cholestasis and Crohn’s disease. In cholestasis impaired bile flow can arise from the dysfunction of bile acid transport to which FABP6 is linked. Furthermore alterations in the protein’s expression or function contribute to Crohn’s disease particularly in the ileal region where it heavily expresses. Mutations and malfunction of related proteins such as FXR and BAAT can complement or exacerbate these issues solidifying the importance of FABP6 in maintaining gut and liver health.
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1 product image
SDS-PAGE - Recombinant Human FABP6 protein (ab87381)
ab87381 on 15% SDS-PAGE (3μg)
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