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AB87381

Recombinant Human FABP6 protein (Tag Free)

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Recombinant Human FABP6 protein (Tag Free) is a Human Full Length protein, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE.

View Alternative Names

ILBP, ILLBP, FABP6, Gastrotropin, GT, Fatty acid-binding protein 6, Ileal lipid-binding protein, Intestinal 15 kDa protein, Intestinal bile acid-binding protein, I-15P, I-BABP

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SDS-PAGE - Recombinant Human FABP6 protein (Tag Free) (AB87381)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human FABP6 protein (Tag Free) (AB87381)

ab87381 on 15% SDS-PAGE (3μg)

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

Tag free

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P51161

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS, 10% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

ab87381 corresponds to isoform 2, 128 aas.
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Sequence info

[{"sequence":"MAFTGKFEMESEKNYDEFMKLLGISSDVIEKAHNFKIVTEVQQDGQDFTWSQHYYGGHTMTNKFTVGKESNIQTMGGKTFKATVQMEGGKLVVNFPNYHQTSEIVGDKLVEVSTIGGVTYERVSKRLA","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P51161","tags":[]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Fatty acid-binding protein 6 (FABP6) also known as ileal bile acid binding protein (IBABP) plays a significant role in binding bile acids. This protein weighs approximately 14 kDa and is prominently expressed in the ileum of the small intestine. It functions primarily within the cytoplasm ensuring the transportation of bile acids to specific locations within cells. By doing this FABP6 facilitates the proper metabolism and absorption of these acids which are critical components for the digestion and absorption of dietary fats.
Biological function summary

The protein plays a critical role in the enterohepatic circulation of bile acids which it binds with high affinity. FABP6 operates within a network of ligands and ions aiding in the homeostasis of bile acids. While it does not directly associate with larger complexes its action contributes to maintaining a balance of cholesterol and fats in the body. It also integrates with other fatty acid-binding proteins like FABP1 and FABP3 which engage in similar transport functions in different tissues.

Pathways

FABP6 functions prominently within the bile acid signaling and lipid metabolism pathways. It interacts closely with proteins such as FXR (Farnesoid X receptor) that senses bile acid concentrations and regulates their synthesis and transport. Additionally FABP6 has relationship with the bile acid-CoA:amino acid N-acyltransferase (BAAT) which is involved in bile acid conjugation. These connections underpin its key role in lipid digestion and cholesterol homeostasis.

FABP6 has associations with cholestasis and Crohn’s disease. In cholestasis impaired bile flow can arise from the dysfunction of bile acid transport to which FABP6 is linked. Furthermore alterations in the protein’s expression or function contribute to Crohn’s disease particularly in the ileal region where it heavily expresses. Mutations and malfunction of related proteins such as FXR and BAAT can complement or exacerbate these issues solidifying the importance of FABP6 in maintaining gut and liver health.
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Specifications

Form

Liquid

Additional notes

Purified by using conventional chromatography techniques.

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General info

Function

Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity). In vitro binds to bile acids in the order : deoxycholic acid > cholic acid > chenodeoxycholic acid and respective BA conjugation modifies affinities in the order taurine-conjugated > glycine-conjugated > unconjugated bile acids. Stimulates gastric acid and pepsinogen secretion (By similarity).. Isoform 2. Essential for the survival of colon cancer cells to bile acid-induced apoptosis.

Sequence similarities

Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

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Product protocols

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Target data

Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity). In vitro binds to bile acids in the order : deoxycholic acid > cholic acid > chenodeoxycholic acid and respective BA conjugation modifies affinities in the order taurine-conjugated > glycine-conjugated > unconjugated bile acids. Stimulates gastric acid and pepsinogen secretion (By similarity).. Isoform 2. Essential for the survival of colon cancer cells to bile acid-induced apoptosis.
See full target information FABP6
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Complementary Products

Primary Antibodies

AB235094

Anti-Bile Acid Receptor NR1H4 antibody

Western blot - Anti-Bile Acid Receptor NR1H4 antibody (AB235094)

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Proteins & Peptides

AB316633

Recombinant Human H-FABP Protein Standard (His tag)

Sandwich ELISA - Recombinant Human H-FABP Protein Standard (His tag) (AB316633)

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Primary Antibodies

AB96122

Anti-FABP6 antibody

Western blot - Anti-FABP6 antibody (AB96122)

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Primary Antibodies

AB203205

Anti-SLC10A2/ASBT antibody

Western blot - Anti-SLC10A2/ASBT antibody (AB203205)

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