Recombinant Human Factor XIa protein (His tag)
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Recombinant Human Factor XIa protein (His tag) is a Human Full Length protein, in the 19 to 387 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.
View Alternative Names
Coagulation factor XI, FXI, Plasma thromboplastin antecedent, PTA, F11
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human Factor XIa protein (His tag) (AB235675)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis with 5% enrichment gel and 15% separation gel of ab235675.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Factor XIa is essential for hemostasis. It forms a part of the intrinsic pathway complex that contributes to the amplification of thrombin generation. This activity strengthens the formation of a stable fibrin clot which is critical to prevent excessive bleeding. Factor XIa is also involved in cellular response mechanisms beyond coagulation such as inflammatory processes.
Pathways
Factor XIa is a significant component of the intrinsic coagulation pathway and the contact activation system. It works closely with proteins like Factor IX and kallikrein facilitating the transformation of inactive proteins to their active states in a stepwise manner. These interactions support hemostatic balance and help maintain proper clot formation while preventing thrombosis.
Specifications
Form
Liquid
General info
Function
Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
Sequence similarities
Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
Post-translational modifications
N-glycosylated on both chains. N-glycosylated sites mainly consist of nonfucosylated sialylated biantennary (in high abundance) and/or triantennary (in low abundance) complex structures. Glycosylation at Asn-163 uses a rare non-canonical Asn-X-Cys glycosite.. Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen. Activated by F12 (activated); the presence of negatively charged surfaces accelerates activation (PubMed:2019570, PubMed:8427954). Activated by F2 (thrombin); the presence of negatively charged surfaces, such as polyphosphate and dextran sulfate, strongly accelerates activation (PubMed:2019570, PubMed:21976677). Autoactivated; the presence of negatively charged surfaces, such as polyphosphate and dextran sulfate, accelerates autoactivation and autolysis (PubMed:2019570, PubMed:21976677).
Target data
Complementary Products
Primary Antibodies
AB320692
Anti-FXI antibody [EPR29297-66] - BSA and Azide free (Detector)
Recombinant|RabMAb
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Product promise
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