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AB276399

Recombinant Human Factor XIII protein (His tag)

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Recombinant Human Factor XIII protein (His tag) is a Human Full Length protein, in the 1 to 661 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.
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SDS-PAGE - Recombinant Human Factor XIII protein (His tag) (AB276399)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Factor XIII protein (His tag) (AB276399)

SDS-PAGE analysis of ab276399

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P05160-1

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS

storage-buffer

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Proteins & Peptides

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Recombinant Human HDHD2 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human HDHD2 protein (His tag N-Terminus) (AB101940)

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Proteins & Peptides

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Proteins & Peptides

AB139209

Recombinant Human LSM12 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human LSM12 protein (His tag N-Terminus) (AB139209)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"linker":null,"sequence":"MRLKNLTFIIILIISGELYAEEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEGWSPEPRCFKKCTKPDLSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYGWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFGWYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRGKWTLPPECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSPPVCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEMEKNNLLLKWDFDNRPHILHGEYIEFICRGDTYPAELYITGSILRMQCDRGQLKYPRCIPRQSTLSYQEPLRT","proteinLength":"Full Length","predictedMolecularWeight":"74.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":661,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"P05160","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Form
Lyophilized
Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Factor XIII also known as fibrin-stabilizing factor is an enzyme that plays a role in blood coagulation. It is a zymogen of approximately 320 kDa expressed primarily in the liver megakaryocytes and placenta. In its active form Factor XIII is a heterotetramer composed of two A subunits and two B subunits. The A subunits are the catalytic parts while the B subunits function as carriers. Factor XIII is widely present in plasma and in platelets aiding in clot stabilization.
Biological function summary

Factor XIII acts to strengthen and stabilize the fibrin clot by cross-linking fibrin molecules. The enzyme is part of a larger complex known as the blood coagulation pathway. Factor XIII becomes activated by thrombin in the presence of calcium ions. Upon activation it catalyzes the formation of covalent bonds between fibrin molecules enhancing the mechanical strength and resistance of the blood clot. This action prevents premature clot lysis and supports wound healing.

Pathways

Factor XIII plays a significant role in the coagulation cascade and fibrinolytic system. In the coagulation pathway it functions downstream of fibrin formation providing cross-linking important to clot integrity. Factor XIII is closely associated with proteins such as fibrinogen and thrombin which are key components in the clotting process. Additionally Factor XIII interacts with the fibrinolytic system connecting to proteins like plasmin that are essential for clot breakdown.

Malfunction or deficiency of Factor XIII can lead to bleeding disorders such as Factor XIII deficiency characterized by a tendency to bleed excessively. This deficiency severely impacts the stabilization of clots resulting in poor wound healing. Additionally abnormal Factor XIII activity can contribute to thrombotic disorders where excessive clot stabilization occurs linking Factor XIII to proteins involved in thrombus formation like fibrin and plasminogen. Understanding these interactions is key in managing related conditions.
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Product protocols

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Target data

The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin.
See full target information F13B

Alternative Names

Coagulation factor XIII B chain, Fibrin-stabilizing factor B subunit, Protein-glutamine gamma-glutamyltransferase B chain, Transglutaminase B chain, F13B
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Product promise

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