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AB174554

Recombinant Human FAIM1 protein (denatured) (His tag N-Terminus)

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Recombinant Human FAIM1 protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 213 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

FAIM1, FAIM, Fas apoptotic inhibitory molecule 1

1 Images
SDS-PAGE - Recombinant Human FAIM1 protein (denatured) (His tag N-Terminus) (AB174554)
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Supplier Data

SDS-PAGE - Recombinant Human FAIM1 protein (denatured) (His tag N-Terminus) (AB174554)

15% SDS-PAGE analysis of ab174554 (3 μg).

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9NVQ4

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMLLPFIRTLPLLCYNHLLVSPDSATLSPPYSLEKMTDLVAVWDVALSDGVHKIEFEHGTTSGKRVVYVDGKEEIRKEWMFKLVGKETFYVGAAKTKATINIDAISGFAYEYTLEINGKSLKKYMEDRSKTTNTWVLHMDGENFRIVLEKDAMDVWCNGKKLETAGEFVDDGTETHFSIGNHDCYIKAVSSGKRKEGIIHTLIVDNREIPEIAS","proteinLength":"Full Length","predictedMolecularWeight":"26.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":213,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NVQ4","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FAIM1 also known as Fas Apoptotic Inhibitory Molecule 1 inhibits apoptosis. This protein has a molecular mass of approximately 24 kDa and comes from expression in various tissues with significant presence in the brain liver and immune cells. FAIM1 blocks apoptotic signals triggered via the Fas receptor also called CD95 ensuring cell survival under certain challenging conditions.
Biological function summary

Functions of FAIM1 support anti-apoptotic activities independent of death receptor pathways. It participates in cellular responses to stress like oxidative stress. The protein does not seem to form a complex but interacts with proteins involved in cell death regulation such as Fas-associated proteins to modulate stress response and survival signaling pathways.

Pathways

FAIM1 shows involvement in apoptosis-related pathways and affects the NF-κB signaling. The protein acts in the molecular framework by inhibiting signals from the Fas receptor collaborating with proteins such as FLIP which also regulate cell death pathways. FAIM1 further influences signaling through NF-κB essential in modulating the immune response.

Research links FAIM1 to neurodegenerative diseases like Alzheimer's disease due to its protective effects against apoptotic cell death. Connections exist between FAIM1 and increased cell survival involving proteins like Bcl-xL which enhance the survival of neurons in stressful environments. FAIM1 also associates with cancer where its overexpression could relate to increased tumor cell survival detailing interactions with oncogenic pathways.
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Specifications

Form

Liquid

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General info

Function

Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells.

Sequence similarities

Belongs to the FAIM1 family.

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Product protocols

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Target data

Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells.
See full target information FAIM
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