Recombinant Human FAIM2/LFG protein

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

FAIM2 also known as Lifeguard (LFG) is a protein that plays a significant role in the prevention of apoptosis. With a mass of approximately 45 kDa it is expressed in various tissues including the nervous system where its expression is prominent. FAIM2 functions by inhibiting Fas-mediated apoptosis which is important in protecting cells from death. It achieves this mechanical function by antagonizing the apoptotic signaling cascades that are initiated by the activation of Fas. The presence of FAIM2 in neural tissues implies its importance in maintaining cell survival under conditions where apoptotic signals might otherwise lead to neuronal loss.

Biological function summary

FAIM2 safeguards cells against apoptosis predominantly through interactions with other key molecules. It exerts its anti-apoptotic effects by modulating the activity of death receptor signaling pathways. FAIM2 acts as an important part of the cellular machinery that prevents inappropriate cell death contributing to the homeostasis of cell populations in tissues. While it does not function as part of a multimeric complex itself its interactions with other proteins like Fas and its downstream effectors further enhance its protective role.

Pathways

FAIM2 is intricately involved in the intrinsic and extrinsic apoptosis pathways. Its role in the extrinsic pathway is emphasized by its interaction with Fas which is a death receptor involved in activating caspases that lead to apoptosis. Additionally FAIM2 influences the intrinsic pathway by interacting with mitochondrial mechanisms that help prevent the release of pro-apoptotic factors. The cross-talk between these pathways highlights the integral role of FAIM2 in maintaining cellular integrity under stress conditions.

Associated diseases and disorders

FAIM2 has been associated with neurodegenerative diseases and certain cancers. Its role in neurodegenerative conditions like Alzheimer's disease is linked to its ability to prevent apoptosis in the nervous system which could otherwise exacerbate neuronal loss. In cancer FAIM2's anti-apoptotic activity can contribute to the survival of cancer cells therefore involving it in tumorigenesis. Through these diseases FAIM2 connects with proteins such as Bcl-2 which similarly regulate apoptotic processes and can impact disease progression.