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AB164382

Recombinant Human FAM108A1 protein (GST tag N-Terminus)

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Recombinant Human FAM108A1 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 361 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

C19orf27, FAM108A1, ABHD17A, Alpha/beta hydrolase domain-containing protein 17A, Abhydrolase domain-containing protein 17A

1 Images
SDS-PAGE - Recombinant Human FAM108A1 protein (GST tag N-Terminus) (AB164382)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human FAM108A1 protein (GST tag N-Terminus) (AB164382)

ab164382 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q96GS6

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MNGLSLSELCCLFCCPPCPGRIAAKLAFLPPEATYSLVPEPEPGPGGAGAAPLGTLRASSGAPGRWKLHLTERADFQYSQRELDTIEVFPTKSARGNRVSCMYVRCVPGARQGHQAQGGHPQLAWVGRLGDSNNPAPGGCLLGESWGTGAALACGYIHLLARYTVLFSHGNAVDLGQMSSFYIGLGSRLHCNIFSYDYSGYGASSGRPSERNLYADIDAAWQALRTRYGISPDSIILYGQSIGTVPTVDLASRYECAAVVLHSPLTSGMRVAFPDTKKTYCFDAFPNIEKVSKITSPVLIIHGTEDEVIDFSHGLALYERCPKAVEPLWVEGAGHNDIELYSQYLERLRRFISQELPSQRA","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":361,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q96GS6","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FAM108A1 also known as Family with Sequence Similarity 108 Member A1 is a poorly characterized protein with an approximate molecular mass of 27 kDa. This protein is expressed throughout various tissues with notably higher levels in neuronal tissues. The protein may possess specific motifs that suggest involvement in cellular processes but the exact mechanical functions remain to be clearly elucidated.
Biological function summary

The protein FAM108A1 is potentially involved in cellular signaling and regulation without forming part of any complex well-defined so far in the literature. Researchers speculate this protein may play a part in the regulation of intracellular pathways that control cell growth and differentiation. Despite limited direct data its expression patterns suggest a biological significance in tissue-specific functions especially in neural connections.

Pathways

Researchers found the involvement of proteins similar to FAM108A1 in fundamental pathways like cell proliferation or intracellular communication. Though specific pathway involvement of FAM108A1 itself is still under investigation proteins like ERK1/2 often surface in studies as potentially interacting partners due to their roles in similar biological processes. Understanding its interaction with known pathways can bring clarity to FAM108A1's function.

Studies suggest an association between the expression patterns of FAM108A1 and certain neurological disorders and cancers. There could be connections to neurodegenerative disorders due to its higher expression in neurons although concrete disease mechanisms are not fully defined. Research into proteins like p53 which have established roles in cancer alongside FAM108A1 might reveal new insights into their mutual associations within these disorders.
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Specifications

Form

Liquid

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General info

Function

Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed : 26701913). Has depalmitoylating activity towards NRAS (PubMed : 26701913). Has depalmitoylating activity towards DLG4/PSD95 (PubMed : 26701913). May have depalmitoylating activity towards MAP6 (By similarity).

Sequence similarities

Belongs to the AB hydrolase superfamily. ABHD17 family.

Post-translational modifications

Palmitoylated on cysteine residues located in a cysteine cluster at the N-terminus which promotes membrane localization (PubMed:26701913). Palmitoylation is required for post-synaptic localization and for depalmitoylating activity towards DLG4/PSD95 (By similarity).

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Product protocols

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Target data

Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed : 26701913). Has depalmitoylating activity towards NRAS (PubMed : 26701913). Has depalmitoylating activity towards DLG4/PSD95 (PubMed : 26701913). May have depalmitoylating activity towards MAP6 (By similarity).
See full target information ABHD17A
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