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AB162416

Recombinant Human FAM108B1 protein (GST tag N-Terminus)

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Recombinant Human FAM108B1 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 288 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

C9orf77, FAM108B1, CGI-67, ABHD17B, Alpha/beta hydrolase domain-containing protein 17B, Abhydrolase domain-containing protein 17B

1 Images
SDS-PAGE - Recombinant Human FAM108B1 protein (GST tag N-Terminus) (AB162416)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human FAM108B1 protein (GST tag N-Terminus) (AB162416)

ab162416 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q5VST6

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MNNLSFSELCCLFCCPPCPGKIASKLAFLPPDPTYTLMCDESGSRWTLHLSERADWQYSSREKDAIECFMTRTSKGNRIACMFVRCSPNAKYTLLFSHGNAVDLGQMSSFYIGLGSRINCNIFSYDYSGYGASSGKPTEKNLYADIEAAWLALRTRYGIRPENVIIYGKSIGTVPSVDLAARYESAAVILHSPLTSGMRVAFPDTKKTYCFDAFPNIDKISKITSPVLIIHGTEDEVIDFSHGLALFERCQRPVEPLWVEGAGHNDVELYGQYLERLKQFVSQELVNL","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":288,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q5VST6","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FAM108B1 also called Family with Sequence Similarity 108 Member B1 represents a protein weighing approximately 32 kDa. Researchers have observed this protein's expression majorly in the testis and the brain suggesting a specific functional role in these tissues. The precise mechanical function remains to be completely defined but FAM108B1 may engage in cellular processes related to its locations of expression.
Biological function summary

Scientists hypothesize that FAM108B1 influences neuronal development and function because of its significant expression in the brain. It does not form part of any known protein complex currently. Its presence in testis indicates a possible involvement in reproductive biology aligning with expression in tissues engaged in foundational biological tasks.

Pathways

Scientists suspect roles for FAM108B1 in pathways like neuronal signaling but direct involvement is still largely unclear. It might interact with proteins involved in neurogenesis or synaptic communication. Due to its presence in testis it might also participate in hormonal regulation pathways although specific synergistic proteins within these pathways are not well-elucidated.

Researchers have yet to fully uncover FAM108B1’s connections. There is a potential link to neurodevelopmental disorders given its expression in the brain might affect neural processes if disrupted. Additionally aberrations in testis-expressed FAM108B1 could associate with certain reproductive dysfunctions though direct connection to disease proteins is not firmly established.
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Specifications

Form

Liquid

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General info

Function

Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed : 26701913). Has depalmitoylating activity towards DLG4/PSD95 (PubMed : 26701913). Has depalmitoylating activity towards GAP43 (By similarity). Has depalmitoylating activity towards MAP6 (By similarity). Has depalmitoylating activity towards NRAS (PubMed : 26701913).

Sequence similarities

Belongs to the AB hydrolase superfamily. ABHD17 family.

Post-translational modifications

Palmitoylated on cysteine residues located in a cysteine cluster at the N-terminus which promotes membrane localization. Palmitoylation is required for post-synaptic localization and for depalmitoylating activity towards DLG4/PSD95.

Subcellular localisation

Recycling endosome membrane

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Product protocols

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Target data

Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed : 26701913). Has depalmitoylating activity towards DLG4/PSD95 (PubMed : 26701913). Has depalmitoylating activity towards GAP43 (By similarity). Has depalmitoylating activity towards MAP6 (By similarity). Has depalmitoylating activity towards NRAS (PubMed : 26701913).
See full target information ABHD17B
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