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AB176049

Recombinant Human FANK1 protein

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Recombinant Human FANK1 protein is a Human Full Length protein, in the 1 to 345 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

HSD13, UNQ6504/PRO21382, FANK1, Fibronectin type 3 and ankyrin repeat domains protein 1

1 Images
SDS-PAGE - Recombinant Human FANK1 protein (AB176049)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human FANK1 protein (AB176049)

15% SDS-PAGE analysis of 3µg ab176049.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q8TC84

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS, 20% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMEPQKIMPPSKPHPPVVGKVTHHSIELYWDLEKKAKRQGPQEQWFRFSIEEEDPKMHTYGIIYTGYATKHVVEGLEPRTLYRFRLKVTSPSGECEYSPLVSVSTTREPISSEHLHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEERKKKQRPKKSCVC","proteinLength":"Full Length","predictedMolecularWeight":"40.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":345,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8TC84","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FANK1 also known as FANK1 precursor is a protein encoded by the FANK1 gene and has a mass of approximately 55 kDa. Mechanically FANK1 has a role in the regulation of gene expression during spermatogenesis with its action specific to cells in the testis where it is highly expressed. The target is most active in the meiotic and post-meiotic phases of sperm cell development indicating its specialized function in male reproductive biology. FANK1’s expression pattern suggests its function closely ties to the development of male gametes.
Biological function summary

The function of FANK1 relates to regulation within the reproductive system where it acts as part of a regulatory network controlling genes vital for sperm maturation. This protein coordinates the expression of a set of target genes necessary for spermatid differentiation and function. Although it does not appear to be part of larger protein complexes FANK1 influences the transcriptional regulation directly essential for proper progression of spermatogenesis. This suggests a tightly controlled mechanism governing male fertility.

Pathways

FANK1 participates in the spermatogenesis pathway impacting the series of events that leads to the production of mature sperm cells. It has connections with other proteins like SYCP3 within the meiotic prophase pathway influencing structural alterations necessary for successful meiosis. The coordination between these proteins ensures correct chromosomal behavior during cell division essential for generating viable sperm.

FANK1 can be connected to male infertility particularly when disruptions occur in spermatogenesis. Aberrant expression or mutations in FANK1 correlate with impaired sperm development and reduced male fertility. This protein shows a disease-associated interaction with transcriptional regulators involved in testicular function further illustrating its importance in maintaining reproductive health. The intricate relationship of FANK1 with spermatogenic pathways reflects its involvement in maintaining the balance required for normal reproductive potential.
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Specifications

Form

Liquid

Additional notes

ab176049 is purified using conventional chromatography techniques.

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General info

Function

Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis.

Post-translational modifications

Polyubiquitinated. Polyubiquitination leads to proteasomal degradation.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis.
See full target information FANK1
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