Recombinant Human Fas protein is a Human Full Length protein, in the 1 to 235 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
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Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
Amino acid sequence
M L G I W T L L P L V L T S V A R L S S K S V N A Q V T D I N S K G L E L R K T V T T V E T Q N L E G L H H D G Q F C H K P C P P G E R K A R D C T V N G D E P D C V P C Q E G K E Y T D K A H F S S K C R R C R L C D E G H G L E V E I N C T R T Q N T K C R C K P N F F C N S T V C E H C D P C T K C E H G I I K E C T L T S N T K C K E E G S R S N L G W L C L L L L P I P L I V W V K R K E V Q K T C R K H R K E N Q G S H E S P T L N P E T V A I N L S D V D L S K Y I T T I A G V M T L S Q V K G F V R K N G V N E A K I D E I K N D N V Q D T A E Q K V Q L L R N W H Q L H G K K E A Y D T L I K D L K K A N L C T L A E K I Q T I I L K D I T S D S E N S N F R N E I Q S L V
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes (Recombinant protein). |
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Target data
Function
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
Alternative names
CD95, APT1, FAS1, TNFRSF6, FAS, Tumor necrosis factor receptor superfamily member 6, Apo-1 antigen, Apoptosis-mediating surface antigen FAS, FASLG receptor
Recommended products
Recombinant Human Fas protein is a Human Full Length protein, in the 1 to 235 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
- Accession
- P25445-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M L G I W T L L P L V L T S V A R L S S K S V N A Q V T D I N S K G L E L R K T V T T V E T Q N L E G L H H D G Q F C H K P C P P G E R K A R D C T V N G D E P D C V P C Q E G K E Y T D K A H F S S K C R R C R L C D E G H G L E V E I N C T R T Q N T K C R C K P N F F C N S T V C E H C D P C T K C E H G I I K E C T L T S N T K C K E E G S R S N L G W L C L L L L P I P L I V W V K R K E V Q K T C R K H R K E N Q G S H E S P T L N P E T V A I N L S D V D L S K Y I T T I A G V M T L S Q V K G F V R K N G V N E A K I D E I K N D N V Q D T A E Q K V Q L L R N W H Q L H G K K E A Y D T L I K D L K K A N L C T L A E K I Q T I I L K D I T S D S E N S N F R N E I Q S L V
- Accession
- P25445
- Protein length
- Full Length
- Predicted molecular weight
- 62.37 kDa
- Amino acids
- 1 to 235
- Nature
- Recombinant
Specifications
- Form
- Liquid
General info
- Function
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
- Post-translational modifications
(Microbial infection) Glycosylated at Arg-250 by enteropathogenic E.coli protein NleB1: arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Product promise
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1 product image
SDS-PAGE - Recombinant Human Fas protein (ab131871)
12.5% SDS-PAGE analysis of ab131871 stained with Coomassie Blue.
Downloads
Product protocols
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