Recombinant Human FAT10 protein
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Recombinant Human FAT10 protein is a Human Full Length protein, in the 1 to 165 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
FAT10, UBD, Ubiquitin D, Diubiquitin, Ubiquitin-like protein FAT10
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human FAT10 protein (AB113594)
SDS-PAGE of ab113594 (3?g) under reducing condition and visualized by coomassie blue stain.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
FAT10 contributes to cellular processes like cell cycle regulation and apoptosis. It forms part of a complex with other ubiquitin-like proteins impacting protein degradation pathways. FAT10's interaction with the proteasome highlights its role in maintaining protein homeostasis and regulating immune response. By tagging proteins for degradation FAT10 influences cellular functions important for adaptation to stress and control of cell proliferation.
Pathways
FAT10 integrates into the NF-kB and TGF-beta pathways. This integration links it to inflammatory responses and tumorigenesis. In the NF-kB pathway FAT10 modulates protein degradation associated with inflammatory signaling and immune regulation. It has connections with other ubiquitin-related proteins such as ubiquitin itself to regulate activities within these pathways impacting cellular responses to external stimuli.
Specifications
Form
Liquid
Additional notes
ab113594 was purified using conventional chromatography.
General info
Function
Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN).
Post-translational modifications
Can be acetylated.
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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