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AB132799

Recombinant Human FATP1 protein

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Recombinant Human FATP1 protein is a Human protein, in the 1 to 646 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

ACSVL5, FATP1, SLC27A1, Long-chain fatty acid transport protein 1, Arachidonate--CoA ligase, Fatty acid transport protein 1, Long-chain-fatty-acid--CoA ligase, Solute carrier family 27 member 1, Very long-chain acyl-CoA synthetase, FATP-1

1 Images
SDS-PAGE - Recombinant Human FATP1 protein (AB132799)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human FATP1 protein (AB132799)

12.5% SDS-PAGE analysis of ab132799 stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, SDS-PAGE, ELISA

applications

Biologically active

No

Accession

Q6PCB7

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MRAPGAGAASVVSLALLWLLGLPWTWSAAAALGVYVGSGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRHQRAGHTIPRIFQAVVQRQPERLALVDAGTGECWTFAQLDAYSNAVANLFRQLGFAPGDVVAIFLEGRPEFVGLWLGLAKAGMEAALLNVNLRREPLAFCLGTSGAKALIFGGEMVAAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTVVQYIGEICRYLLKQPVREAERRHRVRLAVGNGLRPAIWEEFTERFGVRQIGEFYGATECNCSIANMDGKVGSCGFNSRILPHVYPIRLVKVNEDTMELLRDAQGLCIPCQAGEPGLLVGQINQQDPLRRFDGYVSESATSKKIAHSVFSKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEGVLSRLLGQTDVAVYGVAVPGVEGKAGMAAVADPHSLLDPNAIYQELQKVLAPYARPIFLRLLPQVDTTGTFKIQKTRLQREGFDPRQTSDRLFFLDLKQGHYLPLNEAVYTRICSGAFAL","proteinLength":null,"predictedMolecularWeight":"97.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":646,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q6PCB7","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FATP1 also known as Slc27a1 stands for Fatty Acid Transport Protein 1 and plays a significant role in fatty acid uptake and metabolism. It functions as a transporter that facilitates the influx of long-chain fatty acids across cell membranes. FATP1 weighs approximately 63 kDa and exhibits expression mainly in adipose tissue muscle and liver. The presence of FATP1 in these tissues suggests a specialized involvement in energy metabolism and storage processes.
Biological function summary

FATP1 supports critical processes in lipid metabolism and energy balance. It is not just a flexible transporter of fatty acids but also plays a role in the activation of these molecules through acyl-CoA synthetase activity. FATP1 associates with other metabolic enzymes to form functional complexes that optimize lipid utilization. Through these activities FATP1 influences cellular lipid composition and energy homeostasis with significant effects on metabolic health.

Pathways

FATP1 integrates into the intricate network of lipid metabolism and energy pathways. It is linked with the peroxisome proliferator-activated receptor (PPAR) signaling pathway which regulates lipid metabolism and glucose homeostasis. FATP1 interacts with proteins like CD36 and acyl-CoA synthetase long-chain family members enhancing its role in fatty acid uptake and contributing to efficient metabolic processes.

FATP1 shows associations with metabolic syndromes like obesity and type 2 diabetes. Its altered activity or expression contributes to impaired lipid metabolism thereby aggravating these conditions. FATP1 also has connections with proteins like insulin receptor substrate 1 (IRS1) where dysregulation affects insulin signaling pathways. Understanding FATP1's functions and interactions provides insights into potential therapeutic targets for managing metabolic disorders.
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Specifications

Form

Liquid

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General info

Function

Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane (PubMed : 12556534, PubMed : 20530735, PubMed : 21395585, PubMed : 28178239). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism (By similarity). Probably involved in fatty acid transport across the blood barrier (PubMed : 21395585).

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

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Product protocols

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Target data

Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane (PubMed : 12556534, PubMed : 20530735, PubMed : 21395585, PubMed : 28178239). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism (By similarity). Probably involved in fatty acid transport across the blood barrier (PubMed : 21395585).
See full target information SLC27A1
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