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AB162741

Recombinant Human FBXO42 protein (GST tag N-Terminus)

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Recombinant Human FBXO42 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 716 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

FBX42, JFK, KIAA1332, FBXO42, F-box only protein 42, Just one F-box and Kelch domain-containing protein

1 Images
SDS-PAGE - Recombinant Human FBXO42 protein (GST tag N-Terminus) (AB162741)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human FBXO42 protein (GST tag N-Terminus) (AB162741)

ab162741 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q6P3S6

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Proteins & Peptides

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Proteins & Peptides

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Recombinant Human Zinc finger protein 691 (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Zinc finger protein 691 (GST tag N-Terminus) (AB162402)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MASSSDSEDDSFMAVDQEETVLEGTMDQDEEPHPVLEAEETRHNRSMSELPEEVLEYILSFLSPYQEHKTAALVCKQWYRLIKGVAHQCYHGFMKAVQEGNIQWESRTYPYPGTPITQRFSHSACYYDANQSMYVFGGCTQSSCNAAFNDLWRLDLNSKEWIRPLASGSYPSPKAGATLVVYKDLLVLFGGWTRPSPYPLHQPERFFDEIHTYSPSKNWWNCIVTTHGPPPMAGHSSCVIDDKMIVFGGSLGSRQMSNDVWVLDLEQWAWSKPNISGPSPHPRGGQSQIVIDDATILILGGCGGPNALFKDAWLLHMHSGPWAWQPLKVENEEHGAPELWCHPACRVGQCVVVFSQAPSGRAPLSPSLNSRPSPISATPPALVPETREYRSQSPVRSMDEAPCVNGRWGTLRPRAQRQTPSGSREGSLSPARGDGSPILNGGSLSPGTAAVGGSLDSPVQAISPSTPSAPEGYDLKIGLSLAPRRGSLPDQKDLRLGSIDLNWDLKPASSSNPMDGMDNRTVGGSMRHPPEQTNGVHTPPHVASALAGAVSPGALRRSLEAIKAMSSKGPSASAALSPPLGSSPGSPGSQSLSSGETVPIPRPGPAQGDGHSLPPIARRLGHHPPQSLNVGKPLYQSMNCKPMQMYVLDIKDTKEKGRVKWKVFNSSSVVGPPETSLHTVVQGRGELIIFGGLMDKKQNVKYYPKTNALYFVRAKR","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":716,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q6P3S6","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FBXO42 also known as F-box only protein 42 is a component of the SCF (SKP1-CUL1-F-box protein) complex. It belongs to the F-box protein family characterized by an F-box motif of roughly 40 amino acids. FBXO42 has a molecular weight of approximately 72 kDa. It acts as a substrate recognition unit for the proteasome promoting ubiquitination and subsequent proteolysis of target proteins. FBXO42 predominantly expresses in various tissues including the brain liver and heart.
Biological function summary

F-box protein family members like FBXO42 play a vital role in protein turnover and signal transduction. FBXO42 participates in cell cycle regulation and apoptosis through its involvement in the SCF complex. This complex tags proteins for degradation helping to control their levels within the cell. FBXO42 interacts with other components of the ubiquitin-proteasome system ensuring timely degradation of proteins which is essential for maintaining proper cell function and homeostasis.

Pathways

FBXO42 is integrated into key cellular processes such as the cell cycle and apoptosis pathways. It aids in the progression and regulation of these pathways by targeting specific regulatory proteins for degradation such as cyclins and cyclin-dependent kinase inhibitors. FBXO42 works alongside other SCF members like SKP1 and CUL1 coordinating responses required for cell proliferation and death. Such pathway interactions highlight FBXO42's role in maintaining cellular integrity.

Mutations or dysregulation of FBXO42 link it to neurodegenerative diseases and cancer. For example alterations in FBXO42 expression levels have associations with Alzheimer's disease where proteostasis imbalance is a known factor. FBXO42's role in degrading misfolded or damaged proteins makes it relevant in maintaining neuronal health. Similarly FBXO42's dysfunction can contribute to cancer development by failing to regulate cell cycle proteins adequately potentially exacerbating tumor progression. Interactions with proteins like p53 in these pathways emphasize FBXO42's influence in disease mechanisms.
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Specifications

Form

Liquid

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General info

Function

Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation.

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Product protocols

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Target data

Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation.
See full target information FBXO42
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Product promise

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